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GAP1 amino acid permease GAP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853912, updated on 18-Jan-2023

Summary

Gene symbol
GAP1
Gene description
amino acid permease GAP1
Primary source
SGD:S000001747
Locus tag
YKR039W
See related
AllianceGenome:SGD:S000001747
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables L-proline transmembrane transporter activity; beta-alanine transmembrane transporter activity; and polyamine transmembrane transporter activity. Involved in amino acid transport and polyamine transport. Located in cytoplasmic vesicle; fungal-type vacuole lumen; and plasma membrane. Is integral component of plasma membrane. Orthologous to several human genes including SLC7A1 (solute carrier family 7 member 1); SLC7A2 (solute carrier family 7 member 2); and SLC7A3 (solute carrier family 7 member 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See GAP1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (515063..516871)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene tRNA N6-adenosine threonylcarbamoyltransferase Neighboring gene tRNA-Asp Neighboring gene tRNA-Ala Neighboring gene uncharacterized protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in amino acid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in beta-alanine transport IEA
Inferred from Electronic Annotation
more info
 
involved_in nitrogen compound transport IEA
Inferred from Electronic Annotation
more info
 
involved_in organic substance transport IEA
Inferred from Electronic Annotation
more info
 
involved_in phenylalanine transport IEA
Inferred from Electronic Annotation
more info
 
involved_in polyamine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in polyamine transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proline transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in COPII-coated ER to Golgi transport vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in fungal-type vacuole lumen IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in multivesicular body IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
amino acid permease GAP1
NP_012965.3
  • General amino acid permease; involved in uptake of all L-amino acids, some D-amino acids, related compounds, toxic analogs and polyamines; regulated by nitrogen source; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; essential for invasive growth

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    515063..516871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179829.3NP_012965.3  TPA: amino acid permease GAP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012965.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXA2, P19145
    UniProtKB/TrEMBL
    A0A8H4C0L6, N1NZH2
    Conserved Domains (1) summary
    COG0833
    Location:43601
    LysP; Amino acid permease [Amino acid transport and metabolism]