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API5 apoptosis inhibitor 5 [ Homo sapiens (human) ]

Gene ID: 8539, updated on 27-Nov-2024

Summary

Official Symbol
API5provided by HGNC
Official Full Name
apoptosis inhibitor 5provided by HGNC
Primary source
HGNC:HGNC:594
See related
Ensembl:ENSG00000166181 MIM:609774; AllianceGenome:HGNC:594
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AAC11; AAC-11
Summary
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in thyroid (RPKM 18.0), lymph node (RPKM 15.7) and 25 other tissues See more
Orthologs
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Genomic context

See API5 in Genome Data Viewer
Location:
11p12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (43311996..43344529)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (43467432..43499960)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (43333546..43366079)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:43121800-43122300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4639 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:43233497-43234097 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:43234098-43234697 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:43290423-43290924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:43290925-43291424 Neighboring gene heterogeneous nuclear ribonucleoprotein K pseudogene 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:43333299-43334074 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:43372671-43373334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3267 Neighboring gene tetratricopeptide repeat domain 17 Neighboring gene RN7SK pseudogene 287 Neighboring gene peptidylprolyl isomerase A pseudogene 41

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ11587

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fibroblast growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in fibroblast apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of fibroblast apoptotic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane HDA PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
apoptosis inhibitor 5
Names
FIF
antiapoptosis clone 11 protein
cell migration-inducing gene 8 protein
fibroblast growth factor 2-interacting factor 2
migration-inducing protein MIG8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029841.2 RefSeqGene

    Range
    5002..37535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142930.2NP_001136402.1  apoptosis inhibitor 5 isoform a

    See identical proteins and their annotated locations for NP_001136402.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC087276
    Consensus CDS
    CCDS44572.1
    UniProtKB/Swiss-Prot
    B4DGR0, B4DRJ2, B4E283, D3DR21, G3V1C3, O15441, Q9BZZ5, Q9Y4J7
    Related
    ENSP00000431391.1, ENST00000531273.6
    Conserved Domains (2) summary
    sd00044
    Location:6391
    HEAT; HEAT repeat [structural motif]
    pfam05918
    Location:4496
    API5; Apoptosis inhibitory protein 5 (API5)
  2. NM_001142931.2NP_001136403.1  apoptosis inhibitor 5 isoform c

    See identical proteins and their annotated locations for NP_001136403.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region and a small segment in the 3' coding region that results in a frameshift, compared to variant 1. The resulting protein (isoform c) lacks an internal segment in the N-terminal region and has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC087276
    Consensus CDS
    CCDS44573.1
    UniProtKB/Swiss-Prot
    Q9BZZ5
    Related
    ENSP00000402540.2, ENST00000420461.6
    Conserved Domains (1) summary
    pfam05918
    Location:4441
    API5; Apoptosis inhibitory protein 5 (API5)
  3. NM_001243747.2NP_001230676.1  apoptosis inhibitor 5 isoform d

    See identical proteins and their annotated locations for NP_001230676.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region, one of which results in a translational frameshift, compared to variant 1. The resulting protein (isoform d) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC087276
    UniProtKB/TrEMBL
    B4DDR3, E7ETZ6
    Conserved Domains (2) summary
    sd00044
    Location:6391
    HEAT; HEAT repeat [structural motif]
    pfam05918
    Location:4322
    API5; Apoptosis inhibitory protein 5 (API5)
  4. NM_006595.4NP_006586.1  apoptosis inhibitor 5 isoform b

    See identical proteins and their annotated locations for NP_006586.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a small segment in the 3' coding region that results in a frameshift, compared to variant 1. The resulting protein (isoform b) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC087276
    Consensus CDS
    CCDS31465.1
    UniProtKB/Swiss-Prot
    Q9BZZ5
    Related
    ENSP00000368129.3, ENST00000378852.7
    Conserved Domains (2) summary
    sd00044
    Location:6391
    HEAT; HEAT repeat [structural motif]
    pfam05918
    Location:4496
    API5; Apoptosis inhibitory protein 5 (API5)

RNA

  1. NR_024625.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) includes an additional exon in the 5' region, which includes an in-frame stop codon, compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate (NMD), so does not make a functional protein.
    Source sequence(s)
    AC087276

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    43311996..43344529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718359.5XP_006718422.1  apoptosis inhibitor 5 isoform X1

    See identical proteins and their annotated locations for XP_006718422.1

    Conserved Domains (2) summary
    sd00044
    Location:6391
    HEAT; HEAT repeat [structural motif]
    pfam05918
    Location:4496
    API5; Apoptosis inhibitory protein 5 (API5)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    43467432..43499960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370324.1XP_054226299.1  apoptosis inhibitor 5 isoform X1