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API5 apoptosis inhibitor 5 [ Homo sapiens (human) ]

Gene ID: 8539, updated on 3-Jun-2018
Official Symbol
API5provided by HGNC
Official Full Name
apoptosis inhibitor 5provided by HGNC
Primary source
HGNC:HGNC:594
See related
Ensembl:ENSG00000166181 MIM:609774; Vega:OTTHUMG00000166395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AAC11; AAC-11
Summary
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in thyroid (RPKM 18.0), lymph node (RPKM 15.7) and 25 other tissues See more
Orthologs
See API5 in Genome Data Viewer
Location:
11p12
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (43311955..43344530)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (43333505..43366080)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene mannosidase alpha class 1B member 1 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein K pseudogene 3 Neighboring gene tetratricopeptide repeat domain 17 Neighboring gene RNA, 7SK small nuclear pseudogene 287 Neighboring gene peptidyl-prolyl cis-trans isomerase A pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ11587

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibroblast growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of fibroblast apoptotic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
membrane HDA PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Preferred Names
apoptosis inhibitor 5
Names
FIF
antiapoptosis clone 11 protein
cell migration-inducing gene 8 protein
fibroblast growth factor 2-interacting factor 2
migration-inducing protein MIG8

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029841.1 RefSeqGene

    Range
    5001..37576
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142930.1NP_001136402.1  apoptosis inhibitor 5 isoform a

    See identical proteins and their annotated locations for NP_001136402.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK299288, BC017709, BF115210, DA104687
    Consensus CDS
    CCDS44572.1
    UniProtKB/Swiss-Prot
    Q9BZZ5
    Related
    ENSP00000431391.1, OTTHUMP00000232785, ENST00000531273.5, OTTHUMT00000389545
    Conserved Domains (2) summary
    sd00044
    Location:6391
    HEAT; HEAT repeat [structural motif]
    pfam05918
    Location:4495
    API5; Apoptosis inhibitory protein 5 (API5)
  2. NM_001142931.1NP_001136403.1  apoptosis inhibitor 5 isoform c

    See identical proteins and their annotated locations for NP_001136403.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region and a small segment in the 3' coding region that results in a frameshift, compared to variant 1. The resulting protein (isoform c) lacks an internal segment in the N-terminal region and has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK294724, BC017709, BF115210, DA104687
    Consensus CDS
    CCDS44573.1
    UniProtKB/Swiss-Prot
    Q9BZZ5
    Related
    ENSP00000402540.2, OTTHUMP00000232786, ENST00000420461.6, OTTHUMT00000389546
    Conserved Domains (1) summary
    pfam05918
    Location:4441
    API5; Apoptosis inhibitory protein 5 (API5)
  3. NM_001243747.1NP_001230676.1  apoptosis inhibitor 5 isoform d

    See identical proteins and their annotated locations for NP_001230676.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region, one of which results in a translational frameshift, compared to variant 1. The resulting protein (isoform d) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK293303, AY311389, CK904611, DC334531
    UniProtKB/Swiss-Prot
    Q9BZZ5
    UniProtKB/TrEMBL
    B4DDR3
    Conserved Domains (3) summary
    pfam05918
    Location:4322
    API5; Apoptosis inhibitory protein 5 (API5)
    pfam13646
    Location:70112
    HEAT_2; HEAT repeats
    sd00044
    Location:6391
    HEAT; HEAT repeat [structural motif]
  4. NM_006595.3NP_006586.1  apoptosis inhibitor 5 isoform b

    See identical proteins and their annotated locations for NP_006586.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a small segment in the 3' coding region that results in a frameshift, compared to variant 1. The resulting protein (isoform b) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    BC017709, BF115210, DA104687
    Consensus CDS
    CCDS31465.1
    UniProtKB/Swiss-Prot
    Q9BZZ5
    Related
    ENSP00000368129.3, OTTHUMP00000232787, ENST00000378852.7, OTTHUMT00000389547
    Conserved Domains (2) summary
    sd00044
    Location:6391
    HEAT; HEAT repeat [structural motif]
    pfam05918
    Location:4495
    API5; Apoptosis inhibitory protein 5 (API5)

RNA

  1. NR_024625.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) includes an additional exon in the 5' region, which includes an in-frame stop codon, compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate (NMD), so does not make a functional protein.
    Source sequence(s)
    AK304157, BC017709, BF115210, DA104687

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    43311955..43344530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018464.1XP_016873953.1  apoptosis inhibitor 5 isoform X2

  2. XM_017018465.1XP_016873954.1  apoptosis inhibitor 5 isoform X3

    Related
    ENSP00000399341.2, OTTHUMP00000232791, ENST00000455725.6, OTTHUMT00000389552
  3. XM_006718359.4XP_006718422.1  apoptosis inhibitor 5 isoform X1

    See identical proteins and their annotated locations for XP_006718422.1

    Conserved Domains (3) summary
    pfam05918
    Location:4495
    API5; Apoptosis inhibitory protein 5 (API5)
    pfam13646
    Location:70156
    HEAT_2; HEAT repeats
    sd00044
    Location:6391
    HEAT; HEAT repeat [structural motif]
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