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MIC60 Mic60p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853886, updated on 29-Jun-2024

Summary

Gene symbol
MIC60
Gene description
Mic60p
Primary source
FungiDB:YKR016W
Locus tag
YKR016W
See related
SGD:S000001724; AllianceGenome:SGD:S000001724; VEuPathDB:YKR016W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AIM28; FCJ1; FMP13
Summary
Involved in cristae formation and protein import into mitochondrial intermembrane space. Located in mitochondrial crista and mitochondrial crista junction. Part of MICOS complex. Orthologous to human IMMT (inner membrane mitochondrial protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See MIC60 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (469717..471339)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Rab family GTPase YPT52 Neighboring gene uncharacterized protein Neighboring gene E3 ubiquitin-protein ligase HEL1 Neighboring gene uncharacterized protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in cristae formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cristae formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein import into mitochondrial intermembrane space IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein import into mitochondrial intermembrane space IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of MICOS complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of MICOS complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial crista IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial crista junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Mic60p
NP_012941.1
  • Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic60p is also involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; ortholog of mammalian mitofilin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    469717..471339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179806.1NP_012941.1  TPA: Mic60p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012941.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZZY0, B3LRA0, D6VX81, P36112
    UniProtKB/TrEMBL
    A0A8H4BZN8, N1P0V5
    Conserved Domains (1) summary
    pfam09731
    Location:130533
    Mitofilin; Mitochondrial inner membrane protein