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MET14 adenylyl-sulfate kinase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853869, updated on 12-Aug-2025
Official Symbol
MET14
Official Full Name
adenylyl-sulfate kinase
Primary source
SGD:S000001484
Locus tag
YKL001C
See related
AllianceGenome:SGD:S000001484; FungiDB:YKL001C; VEuPathDB:YKL001C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables adenylylsulfate kinase activity. Involved in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) and sulfur amino acid metabolic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Pakistani type. Orthologous to human PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) and PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See MET14 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (438777..439385, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein bS6m MRP17 Neighboring gene ESCRT-III subunit protein DID4 Neighboring gene dynamin-like GTPase VPS1 Neighboring gene polynucleotide adenylyltransferase PAP1

Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. [Construction of high sulphite-producing industrial strain of Saccharomyces cerevisiae]. Qu N, et al. Wei Sheng Wu Xue Bao, 2006 Feb. PMID 16579462
  2. Cloning, nucleotide sequence, and regulation of MET14, the gene encoding the APS kinase of Saccharomyces cerevisiae. Korch C, et al. Mol Gen Genet, 1991 Sep. PMID 1654509
  3. Properties of the purified APS-kinase from Escherichia coli and Saccharomyces cerevisiae. Schriek U, et al. Arch Microbiol, 1986 Jun. PMID 3019265
  4. Isolation and subcloning analysis of functional centromere DNA (CEN11) from Saccharomyces cerevisiae chromosome XI. Fitzgerald-Hayes M, et al. Mol Cell Biol, 1982 Jan. PMID 6287222, Free PMC Article
  5. Differential transcriptional regulation of sulfur assimilation gene homologues in the Saccharomyces carlsbergensis yeast species hybrid. Johannesen PF, et al. FEMS Yeast Res, 2002 Jan. PMID 12702335

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylylsulfate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylylsulfate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylylsulfate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables adenylylsulfate kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cysteine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in hydrogen sulfide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfate assimilation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sulfate assimilation IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sulfur amino acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
Preferred Names
adenylyl-sulfate kinase
NP_012925.3
  • Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    438777..439385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179567.3 → NP_012925.3  TPA: adenylyl-sulfate kinase

    See identical proteins and their annotated locations for NP_012925.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXT6, Q02196
    UniProtKB/TrEMBL
    A0A0L8VM39, A6ZZW5, B3LR84, B5VME9, C7GQG8, C8ZCG6, G2WI32, N1NZE6
    Conserved Domains (1) summary
    TIGR00455
    Location:7 → 192
    apsK; adenylyl-sulfate kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02196.1

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