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AUR1 inositol phosphorylceramide synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853866, updated on 5-Jun-2017
Gene symbol
AUR1
Gene description
inositol phosphorylceramide synthase
Primary source
SGD:S000001487
Locus tag
YKL004W
Gene type
protein coding
RNA name
inositol phosphorylceramide synthase
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
See AUR1 in Map Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (435580..436785)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L14A Neighboring gene Bye1p Neighboring gene mitochondrial 37S ribosomal protein YmS16 Neighboring gene ESCRT-III subunit protein DID4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Sphingolipid Metabolism, organism-specific biosystem (from WikiPathways)
    Sphingolipid Metabolism, organism-specific biosystemSphingolipids are essential components of the plasma membrane in all eukaryotic cells. S. cerevisiae cells make three complex sphingolipids: inositol-phosphoceramide (IPC), mannose-inositol-phosphoc...
  • sphingolipid biosynthesis, organism-specific biosystem (from BIOCYC)
    sphingolipid biosynthesis, organism-specific biosystemGeneral Background : SPHINGOLIPIDS Sphingolipids are a class of lipids derived from the unsaturated aliphatic amino alcohol : SPHINGOSINE that are essential components of the plasma membrane in all ...
  • sphingolipid biosynthesis (yeast), conserved biosystem (from BIOCYC)
    sphingolipid biosynthesis (yeast), conserved biosystemGeneral Background |FRAME: SPHINGOLIPIDS Sphingolipids| are a class of lipids derived from the unsaturated aliphatic amino alcohol |FRAME: SPHINGOSINE| that are essential components of the plasma me...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
inositol phosphoceramide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
inositol phosphoceramide synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
inositolphosphoceramide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
inositol phosphoceramide synthase complex IPI
Inferred from Physical Interaction
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane ISM
Inferred from Sequence Model
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
Names
inositol phosphorylceramide synthase
NP_012922.1
  • Phosphatidylinositol:ceramide phosphoinositol transferase; required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance; also known as IPC synthase

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    435580..436785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179570.1NP_012922.1  TPA: inositol phosphorylceramide synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012922.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P36107
    Conserved Domains (1) summary
    cd03386
    Location:122317
    PAP2_Aur1_like; PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin.
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