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PAN3 PAN-complex poly(A)-binding subunit PAN3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853843, updated on 23-Jul-2026
Official Symbol
PAN3
Official Full Name
PAN-complex poly(A)-binding subunit PAN3
Primary source
SGD:S000001508
Locus tag
YKL025C
See related
AllianceGenome:SGD:S000001508; FungiDB:YKL025C; VEuPathDB:YKL025C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ECM35
Summary
Enables poly(A) binding activity. Involved in nuclear-transcribed mRNA poly(A) tail shortening and postreplication repair. Located in cytoplasm. Part of PAN complex. Orthologous to human PAN3 (poly(A) specific ribonuclease subunit PAN3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See PAN3 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (390240..392279, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene tRNA threonylcarbamoyladenosine dehydratase Neighboring gene glutathione peroxidase GPX1 Neighboring gene bifunctional uridylate/adenylate kinase Neighboring gene Min9p

Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. PAN-orama: three convergent views of a eukaryotic deadenylase. Martin S, et al. Nat Struct Mol Biol, 2014 Jul. PMID 24992224
  2. Deadenylation-a piece of PANcake. Stubbs MT, et al. EMBO J, 2014 Jul 17. PMID 24957528, Free PMC Article
  3. 3'-UTR-dependent deadenylation by the yeast poly(A) nuclease. Lowell JE, et al. Genes Dev, 1992 Nov. PMID 1358757
  4. Poly(A) tail length control in Saccharomyces cerevisiae occurs by message-specific deadenylation. Brown CE, et al. Mol Cell Biol, 1998 Nov. PMID 9774670, Free PMC Article
  5. The structure of the Pan2-Pan3 core complex reveals cross-talk between deadenylase and pseudokinase. Schäfer IB, et al. Nat Struct Mol Biol, 2014 Jul. PMID 24880344

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pan3 functions to supply the exonuclease Pan2 with substrate poly(A) RNA, facilitating efficient mRNA deadenylation.
    Title: Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation.
  2. PAN2 and PAN3 are not required for mRNA poly(A) tail length control during de novo synthesis but may act in conjuction with Pab1p at a later stage in mRNA metabolism.
    Title: Yeast mRNA Poly(A) tail length control can be reconstituted in vitro in the absence of Pab1p-dependent Poly(A) nuclease activity.
  3. Accumulation of polyadenylated mRNAs at sites of transcription occurs in strains lacking the PAN2 or PAN3 subunits of the poly(A) nuclease PAN. PAN is identified as an important factor that couples 3' processing of pre-mRNAs to export.
    Title: Yeast poly(A)-binding protein, Pab1, and PAN, a poly(A) nuclease complex recruited by Pab1, connect mRNA biogenesis to export.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables poly(A) binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage tolerance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in DNA damage tolerance IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA poly(A) tail shortening IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear-transcribed mRNA poly(A) tail shortening IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA poly(A) tail shortening IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of PAN complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PAN complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PAN complex IEA
Inferred from Electronic Annotation
more info
  
part_of PAN complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
PAN-complex poly(A)-binding subunit PAN3
NP_012900.1
  • Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; poly (A) mRNA binding subunit which recruits mRNA to the complex; the Pan2p-Pan3p complex controls poly(A) tail length and regulates the stoichiometry and activity of postreplication repair complexes

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    390240..392279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179591.1 → NP_012900.1  PAN-complex poly(A)-binding subunit PAN3

    See identical proteins and their annotated locations for NP_012900.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXQ9, P36102
    UniProtKB/TrEMBL
    B3LR58
    Conserved Domains (2) summary
    pfam18101
    Location:540 → 675
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:311 → 419
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36102.1

Gene LinkOut

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