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CSE4 centromeric DNA-binding histone H3-like protein CSE4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853817, updated on 7-Oct-2018

Summary

Gene symbol
CSE4
Gene description
centromeric DNA-binding histone H3-like protein CSE4
Primary source
SGD:S000001532
Locus tag
YKL049C
Gene type
protein coding
RNA name
centromeric DNA-binding histone H3-like protein CSE4
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CSL2

Genomic context

See CSE4 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (346075..346764, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Sfk1p Neighboring gene hypothetical protein Neighboring gene serine/threonine protein kinase ELM1 Neighboring gene Anr2p

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
centromeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
2-micrometer plasmid partitioning IMP
Inferred from Mutant Phenotype
more info
PubMed 
kinetochore assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to CENP-A containing chromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
rRNA transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
2-micrometer circle DNA IDA
Inferred from Direct Assay
more info
PubMed 
CENP-A containing nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
chromosome IEA
Inferred from Electronic Annotation
more info
 
chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
condensed nuclear chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
condensed nuclear chromosome, centromeric region IGI
Inferred from Genetic Interaction
more info
PubMed 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
kinetochore IEA
Inferred from Electronic Annotation
more info
 
kinetochore IGI
Inferred from Genetic Interaction
more info
PubMed 
nucleosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
centromeric DNA-binding histone H3-like protein CSE4
NP_012875.2
  • Histone H3-like centromere protein; associated with promoters, accessible chromatin, RNAPII-bound regions; phosphorylated Cse4p associates with centromeres; required for proper kinetochore function; levels regulated by E3 ubiquitin ligase Psh1p; phosphorylation may destabilize defective kinetochores to promote bi-orientation; ubiquitination of N-terminus regulates proteolysis for faithful chromosome segregation; yeast CSE4 can complement mutations in human homolog CENPA

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    346075..346764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179615.1NP_012875.2  TPA: centromeric DNA-binding histone H3-like protein CSE4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012875.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P36012
    Conserved Domains (1) summary
    smart00428
    Location:124229
    H3; Histone H3
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