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SFK1 Sfk1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853815, updated on 18-Sep-2024

Summary

Official Symbol
SFK1
Official Full Name
Sfk1p
Primary source
SGD:S000001534
Locus tag
YKL051W
See related
AllianceGenome:SGD:S000001534; FungiDB:YKL051W; VEuPathDB:YKL051W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in several processes, including inositol lipid-mediated signaling; negative regulation of phospholipid translocation; and vacuole organization. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SFK1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (341312..342373)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Mdm35p Neighboring gene Ask1p Neighboring gene Lpx2p Neighboring gene centromeric DNA-binding histone H3-like protein CSE4

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of phospholipid translocation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of phospholipid translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vacuole organization IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
Sfk1p
NP_012873.1
  • Protein that regulates phospholipid asymmetry at plasma membrane; may act to generate normal levels of PI4P; may act together with or upstream of Stt4p; at least partially mediates proper localization of Stt4p to the plasma membrane

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    341312..342373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179617.1NP_012873.1  TPA: Sfk1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012873.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXN6, P35735
    UniProtKB/TrEMBL
    B3LR38, C7GP23, N1P7V7
    Conserved Domains (1) summary
    pfam10277
    Location:10285
    Frag1; Frag1/DRAM/Sfk1 family