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TOA2 transcription initiation factor IIA subunit gamma [ Saccharomyces cerevisiae S288C ]

Gene ID: 853807, updated on 14-Apr-2023

Summary

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Gene symbol
TOA2
Gene description
transcription initiation factor IIA subunit gamma
Primary source
SGD:S000001541
Locus tag
YKL058W
See related
AllianceGenome:SGD:S000001541
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to TBP-class protein binding activity. Involved in RNA polymerase II preinitiation complex assembly. Part of transcription factor TFIIA complex. Orthologous to human GTF2A2 (general transcription factor IIA subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TOA2 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (330166..330534)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene fructose-bisphosphate aldolase FBA1 Neighboring gene cleavage polyadenylation factor subunit MPE1 Neighboring gene Nup120p Neighboring gene Tma19p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Improved method for soluble expression and rapid purification of yeast TFIIA. Adachi N, et al. Protein Expr Purif, 2017 May. PMID 28259734
  2. The stability of the TFIIA-TBP-DNA complex is dependent on the sequence of the TATAAA element. Stewart JJ, et al. J Biol Chem, 2001 Aug 10. PMID 11402056
  3. Transcriptional activation in yeast cells lacking transcription factor IIA. Chou S, et al. Genetics, 1999 Dec. PMID 10581267, Free PMC Article
  4. High-resolution mapping of nucleoprotein complexes by site-specific protein-DNA photocrosslinking: organization of the human TBP-TFIIA-TFIIB-DNA quaternary complex. Lagrange T, et al. Proc Natl Acad Sci U S A, 1996 Oct 1. PMID 8855228, Free PMC Article
  5. Sequence of a 28.6 kb region of yeast chromosome XI includes the FBA1 and TOA2 genes, an open reading frame (ORF) similar to a translationally controlled tumour protein, one ORF containing motifs also found in plant storage proteins and 13 ORFs with weak or no homology to known proteins. Rasmussen SW. Yeast, 1994 Apr. PMID 8091862

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
contributes_to TBP-class protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in RNA polymerase II preinitiation complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in RNA polymerase II preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIA complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of transcription factor TFIIA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIA complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription initiation factor IIA subunit gamma
NP_012865.1
  • TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa1p, for ribosomal protein gene transcription in vivo; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    330166..330534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179624.1 → NP_012865.1  TPA: transcription initiation factor IIA subunit gamma [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012865.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXM9, P32774
    UniProtKB/TrEMBL
    A0A0L8VM13, A0A6A5PRZ0, A0A6C1DVW1, A6ZZQ8, B3LR33, C7GP16, C8ZCB4, G2WHX4, H0GJ75, N1P094
    Conserved Domains (1) summary
    COG5123
    Location:3 → 122
    TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
5OQJ_V.1
5OQM_V.1
6GYM_V.1
P32774.1

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