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TOA2 transcription initiation factor IIA subunit gamma [ Saccharomyces cerevisiae S288C ]

Gene ID: 853807, updated on 11-Jun-2025
Official Symbol
TOA2
Official Full Name
transcription initiation factor IIA subunit gamma
Primary source
SGD:S000001541
Locus tag
YKL058W
See related
AllianceGenome:SGD:S000001541; FungiDB:YKL058W; VEuPathDB:YKL058W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to TBP-class protein binding activity. Involved in RNA polymerase II preinitiation complex assembly. Part of transcription factor TFIIA complex. Orthologous to human GTF2A2 (general transcription factor IIA subunit 2). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs
all
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See TOA2 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (330166..330534)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene fructose-bisphosphate aldolase FBA1 Neighboring gene cleavage polyadenylation factor subunit MPE1 Neighboring gene Nup120p Neighboring gene Tma19p

Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. High-resolution mapping of nucleoprotein complexes by site-specific protein-DNA photocrosslinking: organization of the human TBP-TFIIA-TFIIB-DNA quaternary complex. Lagrange T, et al. Proc Natl Acad Sci U S A, 1996 Oct 1. PMID 8855228, Free PMC Article
  2. Isolation of two genes that encode subunits of the yeast transcription factor IIA. Ranish JA, et al. Science, 1992 Feb 28. PMID 1546313
  3. Factors involved in specific transcription by mammalian RNA polymerase II: purification and analysis of transcription factor IIA and identification of transcription factor IIJ. Cortes P, et al. Mol Cell Biol, 1992 Jan. PMID 1729613, Free PMC Article
  4. The yeast general transcription factor TFIIA is composed of two polypeptide subunits. Ranish JA, et al. J Biol Chem, 1991 Oct 15. PMID 1918049
  5. Five intermediate complexes in transcription initiation by RNA polymerase II. Buratowski S, et al. Cell, 1989 Feb 24. PMID 2917366

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to TBP-class protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA polymerase II preinitiation complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in RNA polymerase II preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIA complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
transcription initiation factor IIA subunit gamma
NP_012865.1
  • TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa1p, for ribosomal protein gene transcription in vivo; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    330166..330534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179624.1 → NP_012865.1  TPA: transcription initiation factor IIA subunit gamma [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012865.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXM9, P32774
    UniProtKB/TrEMBL
    A6ZZQ8, B3LR33, C7GP16, C8ZCB4, G2WHX4, N1P094
    Conserved Domains (1) summary
    COG5123
    Location:3 → 122
    TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32774.1

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