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TOA2 transcription initiation factor IIA subunit gamma [ Saccharomyces cerevisiae S288C ]

Gene ID: 853807, updated on 8-Sep-2022

Summary

Gene symbol
TOA2
Gene description
transcription initiation factor IIA subunit gamma
Primary source
SGD:S000001541
Locus tag
YKL058W
See related
AllianceGenome:SGD:S000001541
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to TBP-class protein binding activity. Involved in RNA polymerase II preinitiation complex assembly. Part of transcription factor TFIIA complex. Orthologous to human GTF2A2 (general transcription factor IIA subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See TOA2 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (330166..330534)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene fructose-bisphosphate aldolase FBA1 Neighboring gene cleavage polyadenylation factor subunit MPE1 Neighboring gene Nup120p Neighboring gene Tma19p

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the TOA2 gene: The TOA2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

General protein information

Preferred Names
transcription initiation factor IIA subunit gamma
NP_012865.1
  • TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa1p, for ribosomal protein gene transcription in vivo; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    330166..330534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179624.1NP_012865.1  TPA: transcription initiation factor IIA subunit gamma [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012865.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXM9, P32774
    UniProtKB/TrEMBL
    A0A0L8VM13, A0A6A5PRZ0, A0A6C1DVW1, A0A816A0P5, A6ZZQ8, B3LR33, C7GP16, C8ZCB4, G2WHX4, H0GJ75, N1P094
    Conserved Domains (1) summary
    COG5123
    Location:3122
    TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]