TOA2 transcription initiation factor IIA subunit gamma [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: TOA2
Gene description: transcription initiation factor IIA subunit gamma
Primary source: SGD:S000001541
Locus tag: YKL058W
See related: AllianceGenome:SGD:S000001541
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to TBP-class protein binding activity. Involved in RNA polymerase II preinitiation complex assembly. Part of transcription factor TFIIA complex. Orthologous to human GTF2A2 (general transcription factor IIA subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Homologs of the TOA2 gene: The TOA2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Function	Evidence Code	Pubs
enables RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to TBP-class protein binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA polymerase II preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in RNA polymerase II preinitiation complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA polymerase II preinitiation complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIA complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of transcription factor TFIIA complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIA complex	IEA Inferred from Electronic Annotation more info

NP_012865.1

TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa1p, for ribosomal protein gene transcription in vivo; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress