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BARX2 BARX homeobox 2 [ Homo sapiens (human) ]

Gene ID: 8538, updated on 7-Jun-2020

Summary

Official Symbol
BARX2provided by HGNC
Official Full Name
BARX homeobox 2provided by HGNC
Primary source
HGNC:HGNC:956
See related
Ensembl:ENSG00000043039 MIM:604823
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the homeobox transcription factor family. A highly related protein in mouse has been shown to influence cellular processes that control cell adhesion and remodeling of the actin cytoskeleton in myoblast fusion and chondrogenesis. The encoded protein may also play a role in cancer progression. [provided by RefSeq, Jul 2008]
Expression
Biased expression in esophagus (RPKM 46.6), salivary gland (RPKM 29.6) and 9 other tissues See more
Orthologs

Genomic context

See BARX2 in Genome Data Viewer
Location:
11q24.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (129375237..129452279)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (129245879..129322174)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369571 Neighboring gene uncharacterized LOC105369572 Neighboring gene uncharacterized LOC107984410 Neighboring gene ribosomal protein S27 pseudogene 20 Neighboring gene long intergenic non-protein coding RNA 1395

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association search for type 2 diabetes genes in African Americans.
NHGRI GWA Catalog
Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133368, MGC133369

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cartilage condensation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myotube differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
homeobox protein BarH-like 2
Names
BarH-like homeobox 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003658.5NP_003649.2  homeobox protein BarH-like 2

    See identical proteins and their annotated locations for NP_003649.2

    Status: REVIEWED

    Source sequence(s)
    AP003775, BC111432
    Consensus CDS
    CCDS8481.1
    UniProtKB/Swiss-Prot
    Q9UMQ3
    Related
    ENSP00000281437.4, ENST00000281437.6
    Conserved Domains (1) summary
    pfam00046
    Location:136189
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    129375237..129452279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543044.2XP_011541346.1  homeobox protein BarH-like 2 isoform X2

    Conserved Domains (1) summary
    pfam00046
    Location:344
    Homeobox; Homeobox domain
  2. XM_011543043.1XP_011541345.1  homeobox protein BarH-like 2 isoform X1

    Conserved Domains (1) summary
    pfam00046
    Location:90143
    Homeobox; Homeobox domain
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