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NUP100 FG-nucleoporin NUP100 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853796, updated on 8-Feb-2025

Summary

Official Symbol
NUP100
Official Full Name
FG-nucleoporin NUP100
Primary source
SGD:S000001551
Locus tag
YKL068W
See related
AllianceGenome:SGD:S000001551; FungiDB:YKL068W; VEuPathDB:YKL068W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NSP100
Summary
A structural constituent of nuclear pore. Involved in several processes, including mRNA export from nucleus in response to heat stress; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery; and protein localization to nucleus. Part of nuclear pore central transport channel. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia. Orthologous to human NUP98 (nucleoporin 98 and 96 precursor). [provided by Alliance of Genome Resources, Feb 2025]
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Genomic context

See NUP100 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (310199..313078)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene tRNA-Val Neighboring gene uncharacterized protein Neighboring gene tRNA-His Neighboring gene nucleoside diphosphate kinase

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of nuclear pore IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of nuclear pore IGI
Inferred from Genetic Interaction
more info
PubMed 
enables structural constituent of nuclear pore IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables structural constituent of nuclear pore IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA export from nucleus IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in mRNA export from nucleus in response to heat stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into nucleus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein localization to nuclear inner membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of tRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in telomere tethering at nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
part_of nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
 
part_of nuclear pore central transport channel IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear pore central transport channel IEA
Inferred from Electronic Annotation
more info
 
part_of nuclear pore cytoplasmic filaments IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
FG-nucleoporin NUP100
NP_012855.1
  • FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier and is involved in gene tethering at the nuclear periphery; NUP100 has a paralog, NUP116, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    310199..313078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179634.1NP_012855.1  TPA: FG-nucleoporin NUP100 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012855.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXL9, Q02629
    UniProtKB/TrEMBL
    C7GVN9, N1P2B8
    Conserved Domains (4) summary
    pfam04096
    Location:814955
    Nucleoporin2; Nucleoporin autopeptidase
    pfam13634
    Location:429509
    Nucleoporin_FG; Nucleoporin FG repeat region
    pfam15967
    Location:54246
    Nucleoporin_FG2; Nucleoporin FG repeated region
    NF033849
    Location:290566
    ser_rich_anae_1; serine-rich protein