U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MUD2 Mud2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853788, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
MUD2
Official Full Name
Mud2p
Primary source
SGD:S000001557
Locus tag
YKL074C
See related
AllianceGenome:SGD:S000001557; FungiDB:YKL074C; VEuPathDB:YKL074C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables pre-mRNA branch point binding activity. Involved in mRNA branch site recognition. Part of commitment complex. Human ortholog(s) of this gene implicated in developmental delay, dysmorphic facies, and brain anomalies. Orthologous to human U2AF2 (U2 small nuclear RNA auxiliary factor 2). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MUD2 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (294610..296193, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Psg1p Neighboring gene Aan1p Neighboring gene Hsp70 family chaperone LHS1 Neighboring gene Stb6p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. In vivo commitment to splicing in yeast involves the nucleotide upstream from the branch site conserved sequence and the Mud2 protein. Rain JC, et al. EMBO J, 1997 Apr 1. PMID 9130720, Free PMC Article
  2. Conservation of functional domains involved in RNA binding and protein-protein interactions in human and Saccharomyces cerevisiae pre-mRNA splicing factor SF1. Rain JC, et al. RNA, 1998 May. PMID 9582097, Free PMC Article
  3. The yeast MUD2 protein: an interaction with PRP11 defines a bridge between commitment complexes and U2 snRNP addition. Abovich N, et al. Genes Dev, 1994 Apr 1. PMID 7926772
  4. Characterization of a mimivirus RNA cap guanine-N2 methyltransferase. Benarroch D, et al. RNA, 2009 Apr. PMID 19218551, Free PMC Article
  5. Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for sub2, an essential spliceosomal ATPase. Kistler AL, et al. Genes Dev, 2001 Jan 1. PMID 11156604, Free PMC Article

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mud2 is a novel transcription factor that is necessary for the recruitment of mRNA-binding proteins to the transcription machinery. Thus, Mud2 is a multifunctional protein important for transcription, splicing and most likely also mRNP packaging.
    Title: Mud2 functions in transcription by recruiting the Prp19 and TREX complexes to transcribed genes.
  2. BBP/Mud2 influences U1 binding at the 5' splice site by promoting long-lived E complex formation.
    Title: Dynamics and consequences of spliceosome E complex formation.
  3. exploited the synthetic lethal interactions of tgs1Delta and mud2Delta mutations to identify essential structural features of the Tgs1 and Mud2 proteins
    Title: Mutational analyses of trimethylguanosine synthase (Tgs1) and Mud2: proteins implicated in pre-mRNA splicing.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly-pyrimidine tract binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pre-mRNA 3'-splice site binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pre-mRNA branch point binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA branch site recognition IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mRNA branch site recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2AF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of commitment complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of commitment complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of commitment complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Mud2p
NP_012849.1
  • Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    294610..296193 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179640.1 → NP_012849.1  TPA: Mud2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012849.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXL2, P36084
    UniProtKB/TrEMBL
    B3LR16, B5VM81, C7GVN3, N1NZ64
    Conserved Domains (2) summary
    smart00361
    Location:436 → 511
    RRM_1; RNA recognition motif
    PRK12678
    Location:46 → 156
    PRK12678; transcription termination factor Rho; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36084.3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools