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DHR2 RNA helicase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853784, updated on 6-Jul-2026
Official Symbol
DHR2
Official Full Name
RNA helicase
Primary source
SGD:S000001561
Locus tag
YKL078W
See related
AllianceGenome:SGD:S000001561; FungiDB:YKL078W; VEuPathDB:YKL078W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA helicase activity. Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Orthologous to human DHX33 (DEAH-box helicase 33). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See DHR2 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (288845..291052)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene H(+)-transporting V1 sector ATPase subunit C Neighboring gene Smy1p Neighboring gene Psg1p Neighboring gene Aan1p

Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Dhr1p, a putative DEAH-box RNA helicase, is associated with the box C+D snoRNP U3. Colley A, et al. Mol Cell Biol, 2000 Oct. PMID 10982841, Free PMC Article
  2. A Conserved Deubiquitinating Enzyme Uses Intrinsically Disordered Regions to Scaffold Multiple Protein Interaction Sites. Reed BJ, et al. J Biol Chem, 2015 Aug 14. PMID 26149687, Free PMC Article
  3. Comprehensive mutational analysis of yeast DEXD/H box RNA helicases required for small ribosomal subunit synthesis. Granneman S, et al. Mol Cell Biol, 2006 Feb. PMID 16449634, Free PMC Article
  4. The nucleolar protein Nop19p interacts preferentially with Utp25p and Dhr2p and is essential for the production of the 40S ribosomal subunit in Saccharomyces cerevisiae. Choque E, et al. RNA Biol, 2011 Nov-Dec. PMID 21941128, Free PMC Article
  5. TORC1 regulates the transcriptional response to glucose and developmental cycle via the Tap42-Sit4-Rrd1/2 pathway in Saccharomyces cerevisiae. Alfatah M, et al. BMC Biol, 2021 May 6. PMID 33957926, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that Nop19p (renamed from YGR251W) interacts preferentially with the DEAH-box RNA helicase Dhr2p and Utp25p.
    Title: The nucleolar protein Nop19p interacts preferentially with Utp25p and Dhr2p and is essential for the production of the 40S ribosomal subunit in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on RNA IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribonucleoprotein complex biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
Preferred Names
RNA helicase
NP_012845.1
  • Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    288845..291052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179644.1 → NP_012845.1  RNA helicase

    See identical proteins and their annotated locations for NP_012845.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXK9, P36009, Q07040
    UniProtKB/TrEMBL
    B3LR13
    Conserved Domains (1) summary
    COG1643
    Location:30 → 730
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36009.1

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