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SMY1 Smy1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853783, updated on 13-Apr-2024

Summary

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Gene symbol
SMY1
Gene description
Smy1p
Primary source
SGD:S000001562
Locus tag
YKL079W
See related
AllianceGenome:SGD:S000001562
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cytoskeletal motor activity. Involved in vesicle docking involved in exocytosis. Located in cellular bud neck; cellular bud tip; and mating projection tip. Part of incipient cellular bud site. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 2 and schizophrenia. Orthologous to human KIF5C (kinesin family member 5C). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (286603..288573)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene translation elongation factor EF1B gamma Neighboring gene ncRNA Neighboring gene H(+)-transporting V1 sector ATPase subunit C Neighboring gene RNA helicase Neighboring gene Psg1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Scaling of subcellular actin structures with cell length through decelerated growth. McInally SG, et al. Elife, 2021 Jun 11. PMID 34114567, Free PMC Article
  2. Sequence analysis of a 10 kb fragment of yeast chromosome XI identifies the SMY1 locus and reveals sequences related to a pre-mRNA splicing factor and vacuolar ATPase subunit C plus a number of unidentified open reading frames. James CM, et al. Yeast, 1994 Feb. PMID 8203165
  3. The yeast kinesin-related protein Smy1p exerts its effects on the class V myosin Myo2p via a physical interaction. Beningo KA, et al. Mol Biol Cell, 2000 Feb. PMID 10679024, Free PMC Article
  4. Suppression of a myosin defect by a kinesin-related gene. Lillie SH, et al. Nature, 1992 Mar 26. PMID 1549181
  5. A nonprocessive class V myosin drives cargo processively when a kinesin- related protein is a passenger. Hodges AR, et al. Curr Biol, 2009 Dec 29. PMID 20005107, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle docking involved in exocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mating projection tip HDA PubMed 
located_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Smy1p
NP_012844.1
  • Kinesin-like myosin passenger-protein; interacts with Myo2p and enhances its interaction with Sec4p during transport of secretory vesicles; controls actin cable structure and dynamics

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    286603..288573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179645.1 → NP_012844.1  TPA: Smy1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012844.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXK8, P32364
    UniProtKB/TrEMBL
    A0A8H4F912, B3LR12, B5VM77, N1NZ58
    Conserved Domains (2) summary
    COG1196
    Location:254 → 568
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01369
    Location:25 → 364
    KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32364.1

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