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TUBGCP6 tubulin gamma complex associated protein 6 [ Homo sapiens (human) ]

Gene ID: 85378, updated on 21-Mar-2023

Summary

Official Symbol
TUBGCP6provided by HGNC
Official Full Name
tubulin gamma complex associated protein 6provided by HGNC
Primary source
HGNC:HGNC:18127
See related
Ensembl:ENSG00000128159 MIM:610053; AllianceGenome:HGNC:18127
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCP6; GCP-6; MCCRP; MCCRP1; MCPHCR
Summary
The protein encoded by this gene is part of a large multisubunit complex required for microtubule nucleation at the centrosome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 17.1), lymph node (RPKM 14.4) and 25 other tissues See more
Orthologs
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Genomic context

See TUBGCP6 in Genome Data Viewer
Location:
22q13.33
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (50217694..50245023, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (50724656..50752025, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50656123..50683452, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene TraB domain containing Neighboring gene uncharacterized LOC124905148 Neighboring gene selenoprotein O Neighboring gene SELENOO antisense RNA 1 Neighboring gene histone deacetylase 10 Neighboring gene mitogen-activated protein kinase 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Microcephaly and chorioretinopathy 1
MedGen: C3278481 OMIM: 251270 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Gene network analysis in a pediatric cohort identifies novel lung function genes.
EBI GWAS Catalog
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule nucleation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in equatorial microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of gamma-tubulin ring complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
gamma-tubulin complex component 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032160.2 RefSeqGene

    Range
    5000..32329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_020461.4NP_065194.3  gamma-tubulin complex component 6

    Status: REVIEWED

    Source sequence(s)
    AL022328
    Consensus CDS
    CCDS14087.1
    UniProtKB/Swiss-Prot
    Q9UGX4
    Related
    ENSP00000248846.5, ENST00000248846.10
    Conserved Domains (3) summary
    pfam17380
    Location:630834
    DUF5401; Family of unknown function (DUF5401)
    pfam04130
    Location:15131816
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:353610
    GCP_N_terminal; Gamma tubulin complex component N-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    50217694..50245023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_938347.3 RNA Sequence

  2. XR_007067982.1 RNA Sequence

  3. XR_001755343.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    50724656..50752025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008485416.1 RNA Sequence

  2. XR_008485418.1 RNA Sequence

  3. XR_008485417.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001008658.1: Suppressed sequence

    Description
    NM_001008658.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.