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CUE2 Cue2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853772, updated on 15-Mar-2026
Official Symbol
CUE2
Official Full Name
Cue2p
Primary source
SGD:S000001573
Locus tag
YKL090W
See related
AllianceGenome:SGD:S000001573; FungiDB:YKL090W; VEuPathDB:YKL090W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA endonuclease activity and ubiquitin binding activity. Involved in nuclear-transcribed mRNA catabolic process, no-go decay. Is active in cytosolic ribosome. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See CUE2 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (271878..273209)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein BUD2 Neighboring gene phosphatidylinositol/phosphatidylcholine-binding protein Neighboring gene Mif2p Neighboring gene phosphopantothenoylcysteine decarboxylase complex subunit CAB3

Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Yeast elongation factor homolog New1 protects a subset of mRNAs from degradation by no-go decay. Müller M, et al. Nucleic Acids Res, 2026 Jan 22. PMID 41607283, Free PMC Article
  2. Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate no-go decay. Tomomatsu S, et al. Nucleic Acids Res, 2023 Jan 11. PMID 36583309, Free PMC Article
  3. Most, but not all, yeast strains in the deletion library contain the [PIN(+)] prion. Manogaran AL, et al. Yeast, 2010 Mar. PMID 20014044, Free PMC Article
  4. NONU-1 Encodes a Conserved Endonuclease Required for mRNA Translation Surveillance. Glover ML, et al. Cell Rep, 2020 Mar 31. PMID 32234470, Free PMC Article
  5. Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding. Kang RS, et al. Cell, 2003 May 30. PMID 12787503

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate no-go decay.
    Title: Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate no-go decay.
  2. we show that the Cue2-dependent pathway becomes a major contributor to NGD in cells depleted of factors required for the resolution of stalled ribosome complexes.
    Title: The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding TAS
Traceable Author Statement
more info
 PubMed 
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process, no-go decay IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rescue of stalled cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Cue2p
NP_012833.1
  • Ubiquitin-binding endonuclease involved in mRNA decay; recruited to stalled ribosomes to promote breakdown of transcript body of nuclear-transcribed mRNA with stalls in translation elongation; cleaves mRNA within A site of colliding ribosome; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    271878..273209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179656.1 → NP_012833.1  Cue2p

    See identical proteins and their annotated locations for NP_012833.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXJ8, P36075
    UniProtKB/TrEMBL
    A6ZZM7, B5VM67, G2WHU3, N1P291
    Conserved Domains (3) summary
    smart00463
    Location:344 → 440
    SMR; Small MutS-related domain
    cd14374
    Location:10 → 51
    CUE1_Cue2p_like; CUE1 domain found in yeast ubiquitin-binding protein CUE2 (Cue2p) and similar proteins
    cd14375
    Location:57 → 94
    CUE2_Cue2p_like; CUE2 domain found in yeast ubiquitin-binding protein CUE2 (Cue2p) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36075.1

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