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phosphatidylinositol/phosphatidylcholine-binding protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 853771, updated on 24-Jan-2026
Official Full Name
phosphatidylinositol/phosphatidylcholine-binding protein
Primary source
SGD:S000001574
Locus tag
YKL091C
See related
AllianceGenome:SGD:S000001574; FungiDB:YKL091C; VEuPathDB:YKL091C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SFH1
Summary
Enables phosphatidylcholine binding activity and phosphatidylinositol binding activity. Predicted to be involved in post-Golgi vesicle-mediated transport. Located in nucleus. Orthologous to several human genes including SEC14L2 (SEC14 like lipid binding 2); SEC14L3 (SEC14 like lipid binding 3); and SEC14L4 (SEC14 like lipid binding 4). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (269718..270650, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Mbr1p Neighboring gene GTPase-activating protein BUD2 Neighboring gene Cue2p Neighboring gene Mif2p

Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystallization and preliminary X-ray diffraction analysis of phospholipid-bound Sfh1p, a member of the Saccharomyces cerevisiae Sec14p-like phosphatidylinositol transfer protein family. Schaaf G, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Nov 1. PMID 17077504, Free PMC Article
  2. Structural elements that govern Sec14-like PITP sensitivities to potent small molecule inhibitors. Khan D, et al. J Lipid Res, 2016 Apr. PMID 26921357, Free PMC Article
  3. Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily. Schaaf G, et al. Mol Cell, 2008 Feb 1. PMID 18243114, Free PMC Article
  4. Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution. Schaaf G, et al. Mol Biol Cell, 2011 Mar 15. PMID 21248202, Free PMC Article
  5. Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover. Schnabl M, et al. Eur J Biochem, 2003 Aug. PMID 12869188

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phosphatidylcholine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in post-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
phosphatidylinositol/phosphatidylcholine-binding protein
NP_012832.1
  • Putative phosphatidylinositol/phosphatidylcholine transfer protein; possibly involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study; YKL091C has a paralog, SEC14, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    269718..270650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179657.1 → NP_012832.1  phosphatidylinositol/phosphatidylcholine-binding protein

    See identical proteins and their annotated locations for NP_012832.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXJ7, P33324
    UniProtKB/TrEMBL
    A6ZZM6, B3LR03, B5VM66, C7GVL9, C8ZC84, G2WHU2, N1P0I1
    Conserved Domains (2) summary
    smart00516
    Location:101 → 271
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    smart01100
    Location:30 → 75
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33324.2

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