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BUD2 GTPase-activating protein BUD2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853770, updated on 14-Nov-2024

Summary

Official Symbol
BUD2
Official Full Name
GTPase-activating protein BUD2
Primary source
SGD:S000001575
Locus tag
YKL092C
See related
AllianceGenome:SGD:S000001575; FungiDB:YKL092C; VEuPathDB:YKL092C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CLA2; ERC25
Summary
Enables GTPase activator activity. Involved in cellular bud site selection; invasive growth in response to glucose limitation; and mitotic spindle orientation checkpoint signaling. Located in cellular bud neck and incipient cellular bud site. Human ortholog(s) of this gene implicated in artery disease (multiple); autosomal dominant intellectual developmental disorder 5; lung cancer; prostate cancer; and stomach cancer. Orthologous to several human genes including DAB2IP (DAB2 interacting protein); RASAL2 (RAS protein activator like 2); and RASAL3 (RAS protein activator like 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See BUD2 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (266145..269459, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene acylglycerol lipase Neighboring gene Mbr1p Neighboring gene phosphatidylinositol/phosphatidylcholine-binding protein Neighboring gene Cue2p

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
GTPase-activating protein BUD2
NP_012831.1
  • GTPase activating factor for Rsr1p/Bud1p; plays a role in spindle position checkpoint distinct from its role in bud site selection; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; contains two PH-like domains

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    266145..269459 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179658.1NP_012831.1  TPA: GTPase-activating protein BUD2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012831.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXJ6, P33314
    UniProtKB/TrEMBL
    A6ZZM5, G2WHU1, N1P7R7
    Conserved Domains (2) summary
    cd00030
    Location:337444
    C2; C2 domain
    cd05137
    Location:460819
    RasGAP_CLA2_BUD2; Ras-GTPase Activating Domain of CLA2/BUD2