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MICALL1 MICAL like 1 [ Homo sapiens (human) ]

Gene ID: 85377, updated on 7-Jul-2019

Summary

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Official Symbol
MICALL1provided by HGNC
Official Full Name
MICAL like 1provided by HGNC
Primary source
HGNC:HGNC:29804
See related
Ensembl:ENSG00000100139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRAB13; MICAL-L1
Expression
Ubiquitous expression in placenta (RPKM 11.0), esophagus (RPKM 10.9) and 25 other tissues See more
Orthologs
mouse all

Genomic context

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See MICALL1 in Genome Data Viewer
Location:
22q13.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (37906176..37942822)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38302155..38338465)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 54 Neighboring gene eukaryotic translation initiation factor 3 subunit L Neighboring gene RNA, U6 small nuclear 900, pseudogene Neighboring gene chromosome 22 open reading frame 23 Neighboring gene RNA polymerase II subunit F Neighboring gene microRNA 6820

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Regulation of tubular recycling endosome biogenesis by the p53-MICALL1 pathway. Takahashi Y, et al. Int J Oncol, 2017 Aug. PMID 28714518
  2. Novel functions for the endocytic regulatory proteins MICAL-L1 and EHD1 in mitosis. Reinecke JB, et al. Traffic, 2015 Jan. PMID 25287187, Free PMC Article
  3. Diacylglycerol kinase α regulates tubular recycling endosome biogenesis and major histocompatibility complex class I recycling. Xie S, et al. J Biol Chem, 2014 Nov 14. PMID 25248744, Free PMC Article
  4. Regulation of Src trafficking and activation by the endocytic regulatory proteins MICAL-L1 and EHD1. Reinecke JB, et al. J Cell Sci, 2014 Apr 15. PMID 24481818, Free PMC Article
  5. cPLA2α and EHD1 interact and regulate the vesiculation of cholesterol-rich, GPI-anchored, protein-containing endosomes. Cai B, et al. Mol Biol Cell, 2012 May. PMID 22456504, Free PMC Article

See all (36) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  1. Findings found that ectopic expression of MICALL1 significantly inhibited the proliferation of HCT116 colorectal cancer cells. Also, MICALL1 expression was found to be suppressed in colorectal cancer with p53 mutations.
    Title: Regulation of tubular recycling endosome biogenesis by the p53-MICALL1 pathway.
  2. suggesting an EHD1-independent function for MICAL-L1 earlier in mitosis
    Title: Novel functions for the endocytic regulatory proteins MICAL-L1 and EHD1 in mitosis.
  3. DGKalpha generates phosphatidic acid to drive its own recruitment to tubular recycling endosomes via its interaction with MICAL-L1
    Title: Diacylglycerol kinase α regulates tubular recycling endosome biogenesis and major histocompatibility complex class I recycling.
  4. MICAL-L1-mediated recruitment of EHD1 to Src-containing recycling endosomes is required for the release of Src from the perinuclear endocytic recycling compartment in response to growth factor stimulation.
    Title: Regulation of Src trafficking and activation by the endocytic regulatory proteins MICAL-L1 and EHD1.
  5. Cooperation of MICAL-L1, pacsin 2 (syndapin2), and phosphatidic acid in tubular recycling endosome biogenesis.
    Title: Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis.
  6. Rab35 is a critical upstream regulator of MICAL-L1 and Arf6, while both MICAL-L1 and Arf6 regulate Rab8a function.
    Title: MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a.
  7. novel insights into the MICAL-L1/Rab protein complex that can regulate EGFR trafficking at late endocytic pathways.
    Title: MICAL-like1 mediates epidermal growth factor receptor endocytosis.
  8. These data implicate MICAL-L1 as an unusual type of Rab effector that regulates endocytic recycling by recruiting and linking EHD1 and Rab8a on membrane tubules.
    Title: MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ45921, KIAA1668, DKFZp686M2226

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rab GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
cadherin binding HDA PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
  
phosphatidic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
cellular response to nerve growth factor stimulus IEA
Inferred from Electronic Annotation
more info
  
endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
  
plasma membrane tubulation IDA
Inferred from Direct Assay
more info
 PubMed 
protein localization to endosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
retrograde transport, endosome to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
slow endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
NOT early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
extrinsic component of membrane IDA
Inferred from Direct Assay
more info
 PubMed 
late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
recycling endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
NOT recycling endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
NOT trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MICAL-like protein 1
Names
molecule interacting with Rab13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033386.4 → NP_203744.1  MICAL-like protein 1

    See identical proteins and their annotated locations for NP_203744.1

    Status: VALIDATED

    Source sequence(s)
    AJ496196, AL022311, AL834373, CA307559, DR004306
    Consensus CDS
    CCDS13961.1
    UniProtKB/Swiss-Prot
    Q8N3F8
    Related
    ENSP00000215957.6, ENST00000215957.10
    Conserved Domains (3) summary
    cd09444
    Location:164 → 218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4 → 103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:680 → 808
    DUF3585; Protein of unknown function (DUF3585)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    37906176..37942822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029026.1 → XP_016884515.1  MICAL-like protein 1 isoform X6

    Conserved Domains (1) summary
    pfam12130
    Location:447 → 575
    DUF3585; Protein of unknown function (DUF3585)

  2. XM_011530471.2 → XP_011528773.1  MICAL-like protein 1 isoform X1

    Conserved Domains (3) summary
    cd09444
    Location:164 → 218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4 → 103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:737 → 865
    DUF3585; Protein of unknown function (DUF3585)

  3. XM_011530473.2 → XP_011528775.1  MICAL-like protein 1 isoform X3

    Conserved Domains (3) summary
    cd09444
    Location:164 → 218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4 → 103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:737 → 865
    DUF3585; Protein of unknown function (DUF3585)

  4. XM_011530472.2 → XP_011528774.1  MICAL-like protein 1 isoform X2

    Conserved Domains (3) summary
    cd09444
    Location:164 → 218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4 → 103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:735 → 863
    DUF3585; Protein of unknown function (DUF3585)

  5. XM_005261791.3 → XP_005261848.1  MICAL-like protein 1 isoform X4

    Conserved Domains (3) summary
    cd09444
    Location:164 → 218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4 → 103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:680 → 808
    DUF3585; Protein of unknown function (DUF3585)

  6. XM_005261792.3 → XP_005261849.1  MICAL-like protein 1 isoform X5

    Conserved Domains (3) summary
    cd09444
    Location:164 → 218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4 → 103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:678 → 806
    DUF3585; Protein of unknown function (DUF3585)

  7. XM_011530475.2 → XP_011528777.1  MICAL-like protein 1 isoform X6

    Conserved Domains (1) summary
    pfam12130
    Location:447 → 575
    DUF3585; Protein of unknown function (DUF3585)

  8. XM_011530476.2 → XP_011528778.1  MICAL-like protein 1 isoform X7

    Conserved Domains (2) summary
    cd09444
    Location:164 → 218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4 → 103
    CH; Calponin homology (CH) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N3F8.2 GenPept UniProtKB/Swiss-Prot:Q8N3F8

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