U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MICALL1 MICAL like 1 [ Homo sapiens (human) ]

Gene ID: 85377, updated on 5-Nov-2023

Summary

Go to the top of the page Help
Official Symbol
MICALL1provided by HGNC
Official Full Name
MICAL like 1provided by HGNC
Primary source
HGNC:HGNC:29804
See related
Ensembl:ENSG00000100139 MIM:619563; AllianceGenome:HGNC:29804
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRAB13; MICAL-L1
Summary
Enables identical protein binding activity; phosphatidic acid binding activity; and small GTPase binding activity. Involved in several processes, including plasma membrane tubulation; protein localization to endosome; and slow endocytic recycling. Located in late endosome and recycling endosome membrane. Is extrinsic component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta (RPKM 11.0), esophagus (RPKM 10.9) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MICALL1 in Genome Data Viewer
Location:
22q13.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (37906297..37942822)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38367925..38404449)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38302304..38338829)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38245068-38245590 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38245591-38246112 Neighboring gene Sharpr-MPRA regulatory region 5684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38252750-38253250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38253251-38253751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38258557-38259056 Neighboring gene eukaryotic translation initiation factor 3 subunit L Neighboring gene ReSE screen-validated silencer GRCh37_chr22:38276085-38276244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38290604-38291248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38294770-38295536 Neighboring gene RNA, U6 small nuclear 900, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38300995-38301810 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38301811-38302626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38302627-38303442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38303443-38304256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38306246-38307039 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38313076-38313576 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:38313949-38314111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38314373-38314874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38314875-38315374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38329039-38329841 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38329842-38330643 Neighboring gene chromosome 22 open reading frame 23 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13705 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38360913-38361412 Neighboring gene RNA polymerase II, I and III subunit F Neighboring gene microRNA 6820

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. MICAL-L1 is required for cargo protein delivery to the cell surface. Sikora R, et al. Biol Open, 2021 Jun 15. PMID 34100897, Free PMC Article
  2. Defining the protein and lipid constituents of tubular recycling endosomes. Farmer T, et al. J Biol Chem, 2021 Jan-Jun. PMID 33334886, Free PMC Article
  3. MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium. Xie S, et al. J Cell Sci, 2019 Nov 14. PMID 31615969, Free PMC Article
  4. Regulation of tubular recycling endosome biogenesis by the p53-MICALL1 pathway. Takahashi Y, et al. Int J Oncol, 2017 Aug. PMID 28714518
  5. Novel functions for the endocytic regulatory proteins MICAL-L1 and EHD1 in mitosis. Reinecke JB, et al. Traffic, 2015 Jan. PMID 25287187, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MICAL-L1 is required for cargo protein delivery to the cell surface.
    Title: MICAL-L1 is required for cargo protein delivery to the cell surface.
  2. Defining the protein and lipid constituents of tubular recycling endosomes.
    Title: Defining the protein and lipid constituents of tubular recycling endosomes.
  3. A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis.
    Title: A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis.
  4. Data support the notion that a pool of centriolar gamma-tubulin and/or alpha-tubulin-beta-tubulin heterodimers anchor MICAL-L1 to the centriole, where it might recruit EHD1 to promote ciliogenesis.
    Title: MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium.
  5. Findings found that ectopic expression of MICALL1 significantly inhibited the proliferation of HCT116 colorectal cancer cells. Also, MICALL1 expression was found to be suppressed in colorectal cancer with p53 mutations.
    Title: Regulation of tubular recycling endosome biogenesis by the p53-MICALL1 pathway.
  6. suggesting an EHD1-independent function for MICAL-L1 earlier in mitosis
    Title: Novel functions for the endocytic regulatory proteins MICAL-L1 and EHD1 in mitosis.
  7. DGKalpha generates phosphatidic acid to drive its own recruitment to tubular recycling endosomes via its interaction with MICAL-L1
    Title: Diacylglycerol kinase α regulates tubular recycling endosome biogenesis and major histocompatibility complex class I recycling.
  8. MICAL-L1-mediated recruitment of EHD1 to Src-containing recycling endosomes is required for the release of Src from the perinuclear endocytic recycling compartment in response to growth factor stimulation.
    Title: Regulation of Src trafficking and activation by the endocytic regulatory proteins MICAL-L1 and EHD1.
  9. Cooperation of MICAL-L1, pacsin 2 (syndapin2), and phosphatidic acid in tubular recycling endosome biogenesis.
    Title: Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis.
  10. Rab35 is a critical upstream regulator of MICAL-L1 and Arf6, while both MICAL-L1 and Arf6 regulate Rab8a function.
    Title: MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ45921, KIAA1668, DKFZp686M2226

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in plasma membrane tubulation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to endosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in slow endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic side of endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
NOT located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
MICAL-like protein 1
Names
molecule interacting with Rab13

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410818.1 → NP_001397747.1  MICAL-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL022311
    Consensus CDS
    CCDS93161.1
    UniProtKB/TrEMBL
    A0A7P0T9P2, H0Y6J8
    Related
    ENSP00000505762.1, ENST00000680578.1

  2. NM_001410819.1 → NP_001397748.1  MICAL-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL022311
    Consensus CDS
    CCDS93163.1
    UniProtKB/TrEMBL
    B0QY91, H0Y6J8
    Related
    ENSP00000416766.2, ENST00000424008.2

  3. NM_001410820.1 → NP_001397749.1  MICAL-like protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL022311
    Consensus CDS
    CCDS93162.1
    UniProtKB/TrEMBL
    B0QY86, H0Y6J8
    Related
    ENSP00000404543.2, ENST00000445494.6

  4. NM_033386.4 → NP_203744.1  MICAL-like protein 1 isoform 3

    See identical proteins and their annotated locations for NP_203744.1

    Status: VALIDATED

    Source sequence(s)
    AJ496196, AL022311, AL834373, CA307559, DR004306
    Consensus CDS
    CCDS13961.1
    UniProtKB/Swiss-Prot
    Q5TI16, Q7RTP5, Q8N3F8, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45
    UniProtKB/TrEMBL
    H0Y6J8
    Related
    ENSP00000215957.6, ENST00000215957.10
    Conserved Domains (3) summary
    cd09444
    Location:164 → 218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4 → 103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:680 → 808
    DUF3585; Protein of unknown function (DUF3585)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    37906297..37942822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530471.3 → XP_011528773.1  MICAL-like protein 1 isoform X1

    UniProtKB/TrEMBL
    H0Y6J8
    Conserved Domains (3) summary
    cd09444
    Location:164 → 218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4 → 103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:737 → 865
    DUF3585; Protein of unknown function (DUF3585)

  2. XM_011530472.3 → XP_011528774.1  MICAL-like protein 1 isoform X2

    UniProtKB/TrEMBL
    H0Y6J8
    Conserved Domains (3) summary
    cd09444
    Location:164 → 218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4 → 103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:735 → 863
    DUF3585; Protein of unknown function (DUF3585)

  3. XM_047441552.1 → XP_047297508.1  MICAL-like protein 1 isoform X3

    UniProtKB/TrEMBL
    H0Y6J8

  4. XM_005261792.4 → XP_005261849.1  MICAL-like protein 1 isoform X4

    UniProtKB/TrEMBL
    H0Y6J8
    Conserved Domains (3) summary
    cd09444
    Location:164 → 218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4 → 103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:678 → 806
    DUF3585; Protein of unknown function (DUF3585)

  5. XM_017029026.2 → XP_016884515.1  MICAL-like protein 1 isoform X6

    Conserved Domains (1) summary
    pfam12130
    Location:447 → 575
    DUF3585; Protein of unknown function (DUF3585)

  6. XM_011530476.3 → XP_011528778.1  MICAL-like protein 1 isoform X8

    Conserved Domains (2) summary
    cd09444
    Location:164 → 218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4 → 103
    CH; Calponin homology (CH) domain

  7. XM_047441554.1 → XP_047297510.1  MICAL-like protein 1 isoform X5

    UniProtKB/TrEMBL
    H0Y6J8

  8. XM_047441555.1 → XP_047297511.1  MICAL-like protein 1 isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    38367925..38404449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326059.1 → XP_054182034.1  MICAL-like protein 1 isoform X1

    UniProtKB/TrEMBL
    H0Y6J8

  2. XM_054326060.1 → XP_054182035.1  MICAL-like protein 1 isoform X2

    UniProtKB/TrEMBL
    H0Y6J8

  3. XM_054326061.1 → XP_054182036.1  MICAL-like protein 1 isoform X3

    UniProtKB/TrEMBL
    H0Y6J8

  4. XM_054326062.1 → XP_054182037.1  MICAL-like protein 1 isoform X4

    UniProtKB/TrEMBL
    H0Y6J8

  5. XM_054326064.1 → XP_054182039.1  MICAL-like protein 1 isoform X6

  6. XM_054326065.1 → XP_054182040.1  MICAL-like protein 1 isoform X7

  7. XM_054326066.1 → XP_054182041.1  MICAL-like protein 1 isoform X8

  8. XM_054326063.1 → XP_054182038.1  MICAL-like protein 1 isoform X5

    UniProtKB/TrEMBL
    H0Y6J8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N3F8.2 GenPept UniProtKB/Swiss-Prot:Q8N3F8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous