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MICALL1 MICAL like 1 [ Homo sapiens (human) ]

Gene ID: 85377, updated on 5-Feb-2023

Summary

Official Symbol
MICALL1provided by HGNC
Official Full Name
MICAL like 1provided by HGNC
Primary source
HGNC:HGNC:29804
See related
Ensembl:ENSG00000100139 MIM:619563; AllianceGenome:HGNC:29804
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRAB13; MICAL-L1
Summary
Enables identical protein binding activity; phosphatidic acid binding activity; and small GTPase binding activity. Involved in several processes, including plasma membrane tubulation; protein localization to endosome; and slow endocytic recycling. Located in late endosome and recycling endosome membrane. Is extrinsic component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta (RPKM 11.0), esophagus (RPKM 10.9) and 25 other tissues See more
Orthologs
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Genomic context

See MICALL1 in Genome Data Viewer
Location:
22q13.1
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (37906297..37942822)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38367925..38404449)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38302304..38338829)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3 subunit L Neighboring gene RNA, U6 small nuclear 900, pseudogene Neighboring gene chromosome 22 open reading frame 23 Neighboring gene RNA polymerase II, I and III subunit F Neighboring gene microRNA 6820

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45921, KIAA1668, DKFZp686M2226

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in endocytic recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in plasma membrane tubulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to endosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in slow endocytic recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
NOT located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
NOT located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
MICAL-like protein 1
Names
molecule interacting with Rab13

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410818.1NP_001397747.1  MICAL-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL022311
    Consensus CDS
    CCDS93161.1
    UniProtKB/TrEMBL
    A0A7P0T9P2
  2. NM_001410819.1NP_001397748.1  MICAL-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL022311
    Consensus CDS
    CCDS93163.1
    UniProtKB/TrEMBL
    B0QY91
  3. NM_001410820.1NP_001397749.1  MICAL-like protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL022311
    Consensus CDS
    CCDS93162.1
    UniProtKB/TrEMBL
    B0QY86
  4. NM_033386.4NP_203744.1  MICAL-like protein 1 isoform 3

    See identical proteins and their annotated locations for NP_203744.1

    Status: VALIDATED

    Source sequence(s)
    AJ496196, AL022311, AL834373, CA307559, DR004306
    Consensus CDS
    CCDS13961.1
    UniProtKB/Swiss-Prot
    Q8N3F8, Q9UH45
    Related
    ENSP00000215957.6, ENST00000215957.10
    Conserved Domains (3) summary
    cd09444
    Location:164218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:680808
    DUF3585; Protein of unknown function (DUF3585)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    37906297..37942822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530471.3XP_011528773.1  MICAL-like protein 1 isoform X1

    Conserved Domains (3) summary
    cd09444
    Location:164218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:737865
    DUF3585; Protein of unknown function (DUF3585)
  2. XM_011530473.3XP_011528775.1  MICAL-like protein 1 isoform X3

    Related
    ENSP00000505762.1, ENST00000680578.1
    Conserved Domains (3) summary
    cd09444
    Location:164218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:737865
    DUF3585; Protein of unknown function (DUF3585)
  3. XM_011530472.3XP_011528774.1  MICAL-like protein 1 isoform X2

    Conserved Domains (3) summary
    cd09444
    Location:164218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:735863
    DUF3585; Protein of unknown function (DUF3585)
  4. XM_047441552.1XP_047297508.1  MICAL-like protein 1 isoform X4

  5. XM_005261791.4XP_005261848.1  MICAL-like protein 1 isoform X5

    Related
    ENSP00000416766.2, ENST00000424008.2
    Conserved Domains (3) summary
    cd09444
    Location:164218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:680808
    DUF3585; Protein of unknown function (DUF3585)
  6. XM_005261792.4XP_005261849.1  MICAL-like protein 1 isoform X6

    Conserved Domains (3) summary
    cd09444
    Location:164218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:678806
    DUF3585; Protein of unknown function (DUF3585)
  7. XM_047441553.1XP_047297509.1  MICAL-like protein 1 isoform X7

    Related
    ENSP00000404543.2, ENST00000445494.6
  8. XM_017029026.2XP_016884515.1  MICAL-like protein 1 isoform X9

    Conserved Domains (1) summary
    pfam12130
    Location:447575
    DUF3585; Protein of unknown function (DUF3585)
  9. XM_011530476.3XP_011528778.1  MICAL-like protein 1 isoform X11

    Conserved Domains (2) summary
    cd09444
    Location:164218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4103
    CH; Calponin homology (CH) domain
  10. XM_047441554.1XP_047297510.1  MICAL-like protein 1 isoform X8

  11. XM_047441555.1XP_047297511.1  MICAL-like protein 1 isoform X10

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    38367925..38404449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)