MICALL1 MICAL like 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MICALL1provided by HGNC
Official Full Name: MICAL like 1provided by HGNC
Primary source: HGNC:HGNC:29804
See related: Ensembl:ENSG00000100139 MIM:619563; AllianceGenome:HGNC:29804
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRAB13; MICAL-L1
Summary: Enables identical protein binding activity; phosphatidic acid binding activity; and small GTPase binding activity. Involved in several processes, including plasma membrane tubulation; protein localization to endosome; and slow endocytic recycling. Located in late endosome and recycling endosome membrane. Is extrinsic component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta (RPKM 11.0), esophagus (RPKM 10.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 22q13.1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (37906297..37942822)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (38367925..38404449)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (38302304..38338829)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MICAL-L1 is required for cargo protein delivery to the cell surface.
Title: MICAL-L1 is required for cargo protein delivery to the cell surface.
Defining the protein and lipid constituents of tubular recycling endosomes.
Title: Defining the protein and lipid constituents of tubular recycling endosomes.
A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis.
Title: A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis.
Data support the notion that a pool of centriolar gamma-tubulin and/or alpha-tubulin-beta-tubulin heterodimers anchor MICAL-L1 to the centriole, where it might recruit EHD1 to promote ciliogenesis.
Title: MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium.
Findings found that ectopic expression of MICALL1 significantly inhibited the proliferation of HCT116 colorectal cancer cells. Also, MICALL1 expression was found to be suppressed in colorectal cancer with p53 mutations.
Title: Regulation of tubular recycling endosome biogenesis by the p53-MICALL1 pathway.
suggesting an EHD1-independent function for MICAL-L1 earlier in mitosis
Title: Novel functions for the endocytic regulatory proteins MICAL-L1 and EHD1 in mitosis.
DGKalpha generates phosphatidic acid to drive its own recruitment to tubular recycling endosomes via its interaction with MICAL-L1
Title: Diacylglycerol kinase α regulates tubular recycling endosome biogenesis and major histocompatibility complex class I recycling.
MICAL-L1-mediated recruitment of EHD1 to Src-containing recycling endosomes is required for the release of Src from the perinuclear endocytic recycling compartment in response to growth factor stimulation.
Title: Regulation of Src trafficking and activation by the endocytic regulatory proteins MICAL-L1 and EHD1.
Cooperation of MICAL-L1, pacsin 2 (syndapin2), and phosphatidic acid in tubular recycling endosome biogenesis.
Title: Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis.
Rab35 is a critical upstream regulator of MICAL-L1 and Arf6, while both MICAL-L1 and Arf6 regulate Rab8a function.
Title: MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH28521 (e-PCR)
- UniSTS:90757

D11S3114 (e-PCR)
- UniSTS:152207

RH92865 (e-PCR)
- UniSTS:84399

SHGC-33005 (e-PCR)
- UniSTS:14024

Homology

Homologs of the MICALL1 gene: The MICALL1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 472 organisms have orthologs with human gene MICALL1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cadherin binding	HDA more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in plasma membrane tubulation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to endosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in slow endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
NOT located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in extrinsic component of membrane	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
NOT located_in recycling endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	IDA Inferred from Direct Assay more info	PubMed
NOT located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: MICAL-like protein 1

Names: molecule interacting with Rab13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410818.1 → NP_001397747.1 MICAL-like protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL022311

Consensus CDS

CCDS93161.1

UniProtKB/TrEMBL

A0A7P0T9P2
NM_001410819.1 → NP_001397748.1 MICAL-like protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL022311

Consensus CDS

CCDS93163.1

UniProtKB/TrEMBL

B0QY91
NM_001410820.1 → NP_001397749.1 MICAL-like protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AL022311

Consensus CDS

CCDS93162.1

UniProtKB/TrEMBL

B0QY86
NM_033386.4 → NP_203744.1 MICAL-like protein 1 isoform 3

See identical proteins and their annotated locations for NP_203744.1

Status: VALIDATED

Source sequence(s)

AJ496196, AL022311, AL834373, CA307559, DR004306

Consensus CDS

CCDS13961.1

UniProtKB/Swiss-Prot

Q8N3F8, Q9UH45

Related

ENSP00000215957.6, ENST00000215957.10

Conserved Domains (3) summary

cd09444
Location:164 → 218

LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins

pfam00307
Location:4 → 103

CH; Calponin homology (CH) domain

pfam12130
Location:680 → 808

DUF3585; Protein of unknown function (DUF3585)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000022.11 Reference GRCh38.p14 Primary Assembly

Range

37906297..37942822

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011530471.3 → XP_011528773.1 MICAL-like protein 1 isoform X1

Conserved Domains (3) summary

cd09444
Location:164 → 218

LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins

pfam00307
Location:4 → 103

CH; Calponin homology (CH) domain

pfam12130
Location:737 → 865

DUF3585; Protein of unknown function (DUF3585)
XM_011530473.3 → XP_011528775.1 MICAL-like protein 1 isoform X3

Related

ENSP00000505762.1, ENST00000680578.1

Conserved Domains (3) summary

cd09444
Location:164 → 218

LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins

pfam00307
Location:4 → 103

CH; Calponin homology (CH) domain

pfam12130
Location:737 → 865

DUF3585; Protein of unknown function (DUF3585)
XM_011530472.3 → XP_011528774.1 MICAL-like protein 1 isoform X2

Conserved Domains (3) summary

cd09444
Location:164 → 218

LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins

pfam00307
Location:4 → 103

CH; Calponin homology (CH) domain

pfam12130
Location:735 → 863

DUF3585; Protein of unknown function (DUF3585)
XM_047441552.1 → XP_047297508.1 MICAL-like protein 1 isoform X4
XM_005261791.4 → XP_005261848.1 MICAL-like protein 1 isoform X5

Related

ENSP00000416766.2, ENST00000424008.2

Conserved Domains (3) summary

cd09444
Location:164 → 218

LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins

pfam00307
Location:4 → 103

CH; Calponin homology (CH) domain

pfam12130
Location:680 → 808

DUF3585; Protein of unknown function (DUF3585)
XM_005261792.4 → XP_005261849.1 MICAL-like protein 1 isoform X6

Conserved Domains (3) summary

cd09444
Location:164 → 218

LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins

pfam00307
Location:4 → 103

CH; Calponin homology (CH) domain

pfam12130
Location:678 → 806

DUF3585; Protein of unknown function (DUF3585)
XM_047441553.1 → XP_047297509.1 MICAL-like protein 1 isoform X7

Related

ENSP00000404543.2, ENST00000445494.6
XM_017029026.2 → XP_016884515.1 MICAL-like protein 1 isoform X9

Conserved Domains (1) summary

pfam12130
Location:447 → 575

DUF3585; Protein of unknown function (DUF3585)
XM_011530476.3 → XP_011528778.1 MICAL-like protein 1 isoform X11

Conserved Domains (2) summary

cd09444
Location:164 → 218

LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins

pfam00307
Location:4 → 103

CH; Calponin homology (CH) domain
XM_047441554.1 → XP_047297510.1 MICAL-like protein 1 isoform X8
XM_047441555.1 → XP_047297511.1 MICAL-like protein 1 isoform X10