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MICALL1 MICAL like 1 [ Homo sapiens (human) ]

Gene ID: 85377, updated on 17-Jun-2019

Summary

Official Symbol
MICALL1provided by HGNC
Official Full Name
MICAL like 1provided by HGNC
Primary source
HGNC:HGNC:29804
See related
Ensembl:ENSG00000100139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRAB13; MICAL-L1
Expression
Ubiquitous expression in placenta (RPKM 11.0), esophagus (RPKM 10.9) and 25 other tissues See more
Orthologs

Genomic context

See MICALL1 in Genome Data Viewer
Location:
22q13.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (37906176..37942822)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38302155..38338465)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 54 Neighboring gene eukaryotic translation initiation factor 3 subunit L Neighboring gene RNA, U6 small nuclear 900, pseudogene Neighboring gene chromosome 22 open reading frame 23 Neighboring gene RNA polymerase II subunit F Neighboring gene microRNA 6820

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45921, KIAA1668, DKFZp686M2226

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rab GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
cadherin binding HDA PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to nerve growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane tubulation IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to endosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde transport, endosome to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
slow endocytic recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
NOT early endosome IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
NOT recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
NOT trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
MICAL-like protein 1
Names
molecule interacting with Rab13

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033386.4NP_203744.1  MICAL-like protein 1

    See identical proteins and their annotated locations for NP_203744.1

    Status: VALIDATED

    Source sequence(s)
    AJ496196, AL022311, AL834373, CA307559, DR004306
    Consensus CDS
    CCDS13961.1
    UniProtKB/Swiss-Prot
    Q8N3F8
    Related
    ENSP00000215957.6, ENST00000215957.10
    Conserved Domains (3) summary
    cd09444
    Location:164218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:680808
    DUF3585; Protein of unknown function (DUF3585)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    37906176..37942822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029026.1XP_016884515.1  MICAL-like protein 1 isoform X6

    Conserved Domains (1) summary
    pfam12130
    Location:447575
    DUF3585; Protein of unknown function (DUF3585)
  2. XM_011530471.2XP_011528773.1  MICAL-like protein 1 isoform X1

    Conserved Domains (3) summary
    cd09444
    Location:164218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:737865
    DUF3585; Protein of unknown function (DUF3585)
  3. XM_011530473.2XP_011528775.1  MICAL-like protein 1 isoform X3

    Conserved Domains (3) summary
    cd09444
    Location:164218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:737865
    DUF3585; Protein of unknown function (DUF3585)
  4. XM_011530472.2XP_011528774.1  MICAL-like protein 1 isoform X2

    Conserved Domains (3) summary
    cd09444
    Location:164218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:735863
    DUF3585; Protein of unknown function (DUF3585)
  5. XM_005261791.3XP_005261848.1  MICAL-like protein 1 isoform X4

    Conserved Domains (3) summary
    cd09444
    Location:164218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:680808
    DUF3585; Protein of unknown function (DUF3585)
  6. XM_005261792.3XP_005261849.1  MICAL-like protein 1 isoform X5

    Conserved Domains (3) summary
    cd09444
    Location:164218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4103
    CH; Calponin homology (CH) domain
    pfam12130
    Location:678806
    DUF3585; Protein of unknown function (DUF3585)
  7. XM_011530475.2XP_011528777.1  MICAL-like protein 1 isoform X6

    Conserved Domains (1) summary
    pfam12130
    Location:447575
    DUF3585; Protein of unknown function (DUF3585)
  8. XM_011530476.2XP_011528778.1  MICAL-like protein 1 isoform X7

    Conserved Domains (2) summary
    cd09444
    Location:164218
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:4103
    CH; Calponin homology (CH) domain
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