YJU3 acylglycerol lipase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: YJU3
Official Full Name: acylglycerol lipase
Primary source: SGD:S000001577
Locus tag: YKL094W
See related: AllianceGenome:SGD:S000001577; FungiDB:YKL094W; VEuPathDB:YKL094W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables monoacylglycerol lipase activity. Involved in triglyceride metabolic process. Located in lipid droplet and membrane. Orthologous to human MGLL (monoglyceride lipase). [provided by Alliance of Genome Resources, May 2025]
Orthologs: all
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Genomic context

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See YJU3 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (263349..264290)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Present the structure of a monoglyceride lipase from Saccharomyces cerevisiae called Yju3p in its free form and in complex with a covalently bound substrate analog mimicking the tetrahedral intermediate of MG hydrolysis.
Title: Crystal structure of the Saccharomyces cerevisiae monoglyceride lipase Yju3p.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables monoacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info
enables monoacylglycerol lipase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables serine hydrolase activity	HDA more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within acylglycerol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within triglyceride catabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: acylglycerol lipase

NP_012829.1

EC 3.1.1.23

Monoglyceride lipase (MGL) that hydrolyzes fatty acid ethyl esters; required for removal of toxic metabolites in ethanol producing yeast cells; localizes to lipid particles and membranes; member of the eukaryotic serine hydrolase family; functional ortholog of mammalian MGL

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

263349..264290

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179660.1 → NP_012829.1 TPA: acylglycerol lipase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012829.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXJ4, P28321

UniProtKB/TrEMBL

A6ZZM3, B5VM64, C7GVL6, C8ZC81, G2WHT9, N1P058

Conserved Domains (1) summary

COG2267
Location:4 → 310

PldB; Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism]