U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

AAT1 aspartate transaminase AAT1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853755, updated on 3-May-2025
Official Symbol
AAT1
Official Full Name
aspartate transaminase AAT1
Primary source
SGD:S000001589
Locus tag
YKL106W
See related
AllianceGenome:SGD:S000001589; FungiDB:YKL106W; VEuPathDB:YKL106W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable L-aspartate:2-oxoglutarate aminotransferase activity. Involved in alpha-amino acid metabolic process. Is active in mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 82. Orthologous to human GOT2 (glutamic-oxaloacetic transaminase 2). [provided by Alliance of Genome Resources, May 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table
See AAT1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (237536..238891)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene putative short-chain dehydrogenase/reductase Neighboring gene uncharacterized protein Neighboring gene Seg2p Neighboring gene glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1 Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. AAT1, a gene encoding a mitochondrial aspartate aminotransferase in Saccharomyces cerevisiae. Morin PJ, et al. Biochim Biophys Acta, 1992 Dec 29. PMID 1482685
  2. Automation of gene assignments to metabolic pathways using high-throughput expression data. Popescu L, et al. BMC Bioinformatics, 2005 Aug 31. PMID 16135255, Free PMC Article
  3. Recombinant expression of twelve evolutionarily diverse subfamily Ialpha aminotransferases. Muratore KE, et al. Protein Expr Purif, 2008 Jan. PMID 17964807, Free PMC Article
  4. Inactivation of mitochondrial aspartate aminotransferase contributes to the respiratory deficit of yeast frataxin-deficient cells. Sliwa D, et al. Biochem J, 2012 Feb 1. PMID 22010850
  5. Metabolic-flux and network analysis in fourteen hemiascomycetous yeasts. Blank LM, et al. FEMS Yeast Res, 2005 Apr. PMID 15780654

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Secondary inactivation of Aat1 contributes to the amplification of the respiratory defect observed in Deltayfh1 cells.
    Title: Inactivation of mitochondrial aspartate aminotransferase contributes to the respiratory deficit of yeast frataxin-deficient cells.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables L-aspartate:2-oxoglutarate aminotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-aspartate:2-oxoglutarate aminotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-aspartate:2-oxoglutarate aminotransferase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in alpha-amino acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in aspartate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
aspartate transaminase AAT1
NP_012816.1
  • Mitochondrial aspartate aminotransferase; catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    237536..238891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179672.1 → NP_012816.1  TPA: aspartate transaminase AAT1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012816.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXI2, Q01802
    UniProtKB/TrEMBL
    A6ZZL1, B5VM51, G2WHS8, N1P7Q4
    Conserved Domains (1) summary
    COG1448
    Location:21 → 445
    TyrB; Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01802.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous