Format

Send to:

Choose Destination

RAD27 multifunctional nuclease RAD27 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853747, updated on 30-Dec-2017
Gene symbol
RAD27
Gene description
multifunctional nuclease RAD27
Primary source
SGD:S000001596
Locus tag
YKL113C
Gene type
protein coding
RNA name
multifunctional nuclease RAD27
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ERC11; FEN1; RTH1
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (224727..225875, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase PRR1 Neighboring gene DNA-(apurinic or apyrimidinic site) lyase APN1 Neighboring gene DNA-binding protein ABF1 Neighboring gene Kti12p

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
5'-3' exonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
5'-flap endonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
DNA replication IEA
Inferred from Electronic Annotation
more info
 
DNA replication, removal of RNA primer IDA
Inferred from Direct Assay
more info
PubMed 
base-excision repair, base-free sugar-phosphate removal IGI
Inferred from Genetic Interaction
more info
PubMed 
base-excision repair, base-free sugar-phosphate removal IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair via nonhomologous end joining IDA
Inferred from Direct Assay
more info
PubMed 
gene conversion at mating-type locus, DNA repair synthesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of DNA trinucleotide repeats IGI
Inferred from Genetic Interaction
more info
PubMed 
maintenance of DNA trinucleotide repeats IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
replicative cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Names
multifunctional nuclease RAD27
NP_012809.1
  • 5' to 3' exonuclease, 5' flap endonuclease; required for Okazaki fragment processing and maturation, for long-patch base-excision repair and large loop repair (LLR), ribonucleotide excision repair; member of the S. pombe RAD2/FEN1 family; relocalizes to the cytosol in response to hypoxia

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    224727..225875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179679.1NP_012809.1  TPA: multifunctional nuclease RAD27 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012809.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P26793
    Conserved Domains (1) summary
    cl26305
    Location:1364
    XPG_I; XPG I-region
Support Center