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RAD27 multifunctional nuclease RAD27 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853747, updated on 14-Sep-2021

Summary

Gene symbol
RAD27
Gene description
multifunctional nuclease RAD27
Primary source
SGD:S000001596
Locus tag
YKL113C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ERC11; FEN1; RTH1
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Genomic context

See RAD27 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (224727..225875, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase PRR1 Neighboring gene DNA-(apurinic or apyrimidinic site) lyase APN1 Neighboring gene DNA-binding protein ABF1 Neighboring gene Kti12p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the RAD27 gene: The RAD27 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables 5'-3' exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 5'-3' exonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 5'-3' exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables 5'-flap endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 5'-flap endonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 5'-flap endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
multifunctional nuclease RAD27
NP_012809.1
  • 5' to 3' exonuclease, 5' flap endonuclease; required for Okazaki fragment processing and maturation, for long-patch base-excision repair and large loop repair (LLR), ribonucleotide excision repair; member of the S. pombe RAD2/FEN1 family; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    224727..225875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179679.1NP_012809.1  TPA: multifunctional nuclease RAD27 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012809.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P26793
    Conserved Domains (1) summary
    PTZ00217
    Location:1364
    PTZ00217; flap endonuclease-1; Provisional
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