RRN3 rDNA-binding RNA polymerase I transcriptional factor [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RRN3
Official Full Name: rDNA-binding RNA polymerase I transcriptional factor
Primary source: SGD:S000001608
Locus tag: YKL125W
See related: AllianceGenome:SGD:S000001608; FungiDB:YKL125W; VEuPathDB:YKL125W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables several functions, including RNA polymerase I core binding activity; RNA polymerase I general transcription initiation factor activity; and RNA polymerase I general transcription initiation factor binding activity. Involved in transcription initiation at RNA polymerase I promoter. Located in nucleolus. Orthologous to several human genes including RRN3 (RRN3 homolog, RNA polymerase I transcription factor). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See RRN3 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (208247..210130)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that Rpa49, Rrn3 and Mot1 directly or indirectly influence biogenesis
Title: Identification of factors that promote biogenesis of tRNA(CGA)(Ser).
Rrn3 binding converts an inactive RNA polymerase I dimer into an initiation-competent monomeric complex.Rrn3 stabilizes monomeric RNA polymerase I.
Title: RNA polymerase I-Rrn3 complex at 4.8 Å resolution.
A dual role for Rrn3 in transcription initiation to stabilize a monomeric initiation competent RNA polymerase I and to drive pre-initiation complex formation.
Title: Structure of the initiation-competent RNA polymerase I and its implication for transcription.
Two RNA polymerase I subunits control the binding and release of RRN3 during transcription.
Title: Two RNA polymerase I subunits control the binding and release of Rrn3 during transcription.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA polymerase I core binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase I core binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase I core binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase I general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase I general transcription initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase I general transcription initiation factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase I general transcription initiation factor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables RNA polymerase I general transcription initiation factor activity	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase I general transcription initiation factor binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase I general transcription initiation factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables rDNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in transcription initiation at RNA polymerase I promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase I promoter	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at RNA polymerase I promoter	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rDNA-binding RNA polymerase I transcriptional factor

NP_012797.1

Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

208247..210130

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179691.1 → NP_012797.1 rDNA-binding RNA polymerase I transcriptional factor

See identical proteins and their annotated locations for NP_012797.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VX70, P36070

UniProtKB/TrEMBL

A6ZZJ5, N1P304

Conserved Domains (1) summary

pfam05327
Location:45 → 618

RRN3; RNA polymerase I specific transcription initiation factor RRN3