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YPK1 serine/threonine protein kinase YPK1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853733, updated on 18-Jan-2023

Summary

Gene symbol
YPK1
Gene description
serine/threonine protein kinase YPK1
Primary source
SGD:S000001609
Locus tag
YKL126W
See related
AllianceGenome:SGD:S000001609
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SLI2
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including cellular response to acetate; eisosome assembly; and protein phosphorylation. Located in cellular bud neck; cytosol; and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); colorectal cancer (multiple); glucose metabolism disease (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including SGK1 (serum/glucocorticoid regulated kinase 1) and SGK2 (serum/glucocorticoid regulated kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See YPK1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (205707..207749)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene tRNA-Lys Neighboring gene phosphoglucomutase PGM1 Neighboring gene rDNA-binding RNA polymerase I transcriptional factor Neighboring gene Ssh4p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the YPK1 gene: The YPK1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.
  • Orthologs

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to acetate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in eisosome assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in glycerophospholipid metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in glycerophospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of phospholipid translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of fungal-type cell wall organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to pheromone triggering conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine protein kinase YPK1
NP_012796.1
  • S/T protein kinase; required for PM lipid and protein homeostasis; involved in sphingolipid-mediated and cell integrity signaling pathways and endocytosis; phosphorylates and downregulates Fpk1p; phosphorylates and inactivates Orm1p/2p when sphingolipid synthesis is compromised; role in TORC1/2-dependent Rps6a/b phosphorylation; phosphorylated and activated by TORC2 and by Pkh1/2p in the presence of phytosphingosine; human homolog SGK1 complements the null and inviability of a ypk1 ypk2 mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    205707..207749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179692.1NP_012796.1  TPA: serine/threonine protein kinase YPK1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012796.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VX69, P12688
    UniProtKB/TrEMBL
    A0A8H4F8R4, N1P163
    Conserved Domains (2) summary
    cd11651
    Location:116342
    YPK1_N_like; Fungal protein kinase domain similar to the N-terminus of YPK1
    cl21453
    Location:352663
    PKc_like; Protein Kinases, catalytic domain