PGM1 phosphoglucomutase PGM1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PGM1
Official Full Name: phosphoglucomutase PGM1
Primary source: SGD:S000001610
Locus tag: YKL127W
See related: AllianceGenome:SGD:S000001610; FungiDB:YKL127W; VEuPathDB:YKL127W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phosphoglucomutase activity. Involved in several processes, including UDP-alpha-D-glucose metabolic process; carbohydrate biosynthetic process; and glucose 1-phosphate metabolic process. Located in cytoplasm. Used to study congenital disorder of glycosylation It. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation It; endometrial cancer; and teratoma. Orthologous to several human genes including PGM5 (phosphoglucomutase 5). [provided by Alliance of Genome Resources, May 2025]
Orthologs: all
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Genomic context

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See PGM1 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (203541..205253)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

elevated levels of phosphoglucomutase activity allow for the more efficient utilization of the limiting levels of glucose-1-phosphate that are present in the RAS2(val19) mutant.
Title: Increased phosphoglucomutase activity suppresses the galactose growth defect associated with elevated levels of Ras signaling in S. cerevisiae.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoglucomutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoglucomutase activity	IEA Inferred from Electronic Annotation more info
enables phosphoglucomutase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in UDP-alpha-D-glucose metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in carbohydrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in galactose catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glucose 1-phosphate metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glucose 6-phosphate metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in trehalose biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphoglucomutase PGM1

NP_012795.1

EC 5.4.2.2

Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; PGM1 has a paralog, PGM2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

203541..205253

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179693.1 → NP_012795.1 TPA: phosphoglucomutase PGM1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012795.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VX68, P33401

UniProtKB/TrEMBL

A6ZZJ3, G2WHR0, N1P8D1

Conserved Domains (1) summary

cl38939
Location:8 → 570

phosphohexomutase; The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine ...