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CMC1 Cmc1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853721, updated on 5-Jul-2025
Official Symbol
CMC1
Official Full Name
Cmc1p
Primary source
SGD:S000001620
Locus tag
YKL137W
See related
AllianceGenome:SGD:S000001620; FungiDB:YKL137W; VEuPathDB:YKL137W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables copper ion binding activity. Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrial intermembrane space. Orthologous to human CMC1 (C-X9-C motif containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See CMC1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (185957..186292)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Hsk3p Neighboring gene mitochondrial 54S ribosomal protein mL60 MRPL31 Neighboring gene Apl2p Neighboring gene metalloendopeptidase

Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Mia40 is a trans-site receptor that drives protein import into the mitochondrial intermembrane space by hydrophobic substrate binding. Peleh V, et al. Elife, 2016 Jun 25. PMID 27343349, Free PMC Article
  2. Role of twin Cys-Xaa9-Cys motif cysteines in mitochondrial import of the cytochrome C oxidase biogenesis factor Cmc1. Bourens M, et al. J Biol Chem, 2012 Sep 7. PMID 22767599, Free PMC Article
  3. The conserved mitochondrial twin Cx9C protein Cmc2 Is a Cmc1 homologue essential for cytochrome c oxidase biogenesis. Horn D, et al. J Biol Chem, 2010 May 14. PMID 20220131, Free PMC Article
  4. Cmc1p is a conserved mitochondrial twin CX9C protein involved in cytochrome c oxidase biogenesis. Horn D, et al. Mol Cell Biol, 2008 Jul. PMID 18443040, Free PMC Article
  5. Inaccurately assembled cytochrome c oxidase can lead to oxidative stress-induced growth arrest. Bode M, et al. Antioxid Redox Signal, 2013 May 1. PMID 23198688, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of twin Cys-Xaa9-Cys motif cysteines in mitochondrial import of the cytochrome C oxidase biogenesis factor Cmc1.
    Title: Role of twin Cys-Xaa9-Cys motif cysteines in mitochondrial import of the cytochrome C oxidase biogenesis factor Cmc1.
  2. These results suggest that Cmc1p could play a direct or indirect role in copper trafficking and distribution to COX and Sod1p.
    Title: Cmc1p is a conserved mitochondrial twin CX9C protein involved in cytochrome c oxidase biogenesis.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables copper ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitochondrial cytochrome c oxidase assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Cmc1p
NP_012785.2
  • Copper-binding protein of the mitochondrial intermembrane space; evolutionarily conserved; may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    185957..186292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179703.1 → NP_012785.2  TPA: Cmc1p

    See identical proteins and their annotated locations for NP_012785.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZZI5, B3LQW4, D6VX60, P36064
    UniProtKB/TrEMBL
    C7GVI0, C8ZC39, G2WHQ2, N1P158
    Conserved Domains (1) summary
    pfam08583
    Location:30 → 97
    Cmc1; Cytochrome c oxidase biogenesis protein Cmc1 like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36064.2

Gene LinkOut

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