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TGL1 sterol esterase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853717, updated on 17-May-2024

Summary

Gene symbol
TGL1
Gene description
sterol esterase
Primary source
FungiDB:YKL140W
Locus tag
YKL140W
See related
SGD:S000001623; AllianceGenome:SGD:S000001623; VEuPathDB:YKL140W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YKL5
Summary
Enables sterol esterase activity. Involved in cellular lipid metabolic process and sterol metabolic process. Located in lipid droplet. Is integral component of membrane. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; cholesterol ester storage disease; and lysosomal and lipase deficiency. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPK (lipase family member K). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See TGL1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (180779..182425)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Mrp8p Neighboring gene succinate dehydrogenase cytochrome b subunit SDH3 Neighboring gene cyclin-dependent serine/threonine protein kinase CTK1 Neighboring gene Hsk3p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables sterol esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sterol esterase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sterol esterase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sterol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sterol esterase
NP_012782.1
  • Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    180779..182425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179706.1NP_012782.1  TPA: sterol esterase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012782.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VX56, P34163
    UniProtKB/TrEMBL
    A0A8H4FA75, A6ZZI1, C7GVH6, G2WHP8, N1P2Z2
    Conserved Domains (2) summary
    pfam00561
    Location:106402
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam04083
    Location:66124
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region