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TGL1 sterol esterase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853717, updated on 7-Jun-2026
Official Symbol
TGL1
Official Full Name
sterol esterase
Primary source
SGD:S000001623
Locus tag
YKL140W
See related
AllianceGenome:SGD:S000001623; FungiDB:YKL140W; VEuPathDB:YKL140W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YKL5
Summary
Enables sterol ester esterase activity. Involved in sterol metabolic process. Located in lipid droplet and membrane. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See TGL1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (180779..182425)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Mrp8p Neighboring gene succinate dehydrogenase cytochrome b subunit SDH3 Neighboring gene cyclin-dependent serine/threonine protein kinase CTK1 Neighboring gene Hsk3p

Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The lipid droplet enzyme Tgl1p hydrolyzes both steryl esters and triglycerides in the yeast, Saccharomyces cerevisiae. Jandrositz A, et al. Biochim Biophys Acta, 2005 Jun 15. PMID 15922657
  2. Derivatization-independent cholesterol analysis in crude lipid extracts by liquid chromatography/mass spectrometry: applications to a rabbit model for atherosclerosis. Shui G, et al. J Chromatogr A, 2011 Jul 15. PMID 21621788
  3. Vacuolar transport and function of Saccharomyces cerevisiae sterol ester hydrolase Tgl1. Nakatsuji T, et al. FEBS Lett, 2026 Jan. PMID 41108721, Free PMC Article
  4. Characterization of sterol-ester hydrolase in Saccharomyces cerevisiae. Taketani S, et al. Biochim Biophys Acta, 1978 Jul 7. PMID 28772
  5. Mature lipid droplets are accessible to ER luminal proteins. Mishra S, et al. J Cell Sci, 2016 Oct 15. PMID 27591256

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study demonstrates a strong regulation of the two lipid droplet associated steryl ester hydrolases Tgl1p and Yeh1p due to the presence/absence of their host organelle.
    Title: The impact of nonpolar lipids on the regulation of the steryl ester hydrolases Tgl1p and Yeh1p in the yeast Saccharomyces cerevisiae.
  2. A deletion of TGL1 resulted in an increase of the cellular steryl ester content
    Title: The lipid droplet enzyme Tgl1p hydrolyzes both steryl esters and triglycerides in the yeast, Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables sterol ester esterase activity EXP
Inferred from Experiment
more info
 PubMed 
enables sterol ester esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sterol ester esterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sterol ester esterase activity IEA
Inferred from Electronic Annotation
more info
  
enables sterol ester esterase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sterol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in lipid droplet EXP
Inferred from Experiment
more info
 PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
sterol esterase
NP_012782.1
  • Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; major sterol ester hydrolase in the vacuole; contributes to the formation of vacuolar membrane microdomains after the diauxic shift; localized to lipid particle membranes

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    180779..182425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179706.1 → NP_012782.1  sterol esterase

    See identical proteins and their annotated locations for NP_012782.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VX56, P34163
    UniProtKB/TrEMBL
    A6ZZI1, C7GVH6, G2WHP8, N1P2Z2
    Conserved Domains (2) summary
    pfam00561
    Location:106 → 402
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam04083
    Location:66 → 124
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34163.1

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