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SDH1 succinate dehydrogenase flavoprotein subunit SDH1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853709, updated on 7-Jun-2026
Official Symbol
SDH1
Official Full Name
succinate dehydrogenase flavoprotein subunit SDH1
Primary source
SGD:S000001631
Locus tag
YKL148C
See related
AllianceGenome:SGD:S000001631; FungiDB:YKL148C; VEuPathDB:YKL148C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables flavin adenine dinucleotide binding activity and succinate dehydrogenase (quinone) activity. Involved in mitochondrial electron transport, succinate to ubiquinone. Located in mitochondrial membrane. Part of respiratory chain complex II (succinate dehydrogenase). Used to study several diseases, including Leigh disease; endocrine organ benign neoplasm (multiple); gastrointestinal stromal tumor; leukodystrophy; and mitochondrial complex II deficiency. Human ortholog(s) of this gene implicated in Leigh disease; dilated cardiomyopathy 1GG; lung non-small cell carcinoma; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHA (succinate dehydrogenase complex flavoprotein subunit A). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See SDH1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (169207..171129, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene cytochrome-b5 reductase Neighboring gene RNA lariat debranching enzyme Neighboring gene Avt3p Neighboring gene proteasome regulatory particle base subunit RPT1

Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. SDH1, the gene encoding the succinate dehydrogenase flavoprotein subunit from Saccharomyces cerevisiae. Chapman KB, et al. Gene, 1992 Sep 1. PMID 1511876
  2. Primary structure, import, and assembly of the yeast homolog of succinate dehydrogenase flavoprotein. Schülke N, et al. Proc Natl Acad Sci U S A, 1992 Sep 1. PMID 1518827, Free PMC Article
  3. Isolation and nucleotide sequence of the Saccharomyces cerevisiae gene for the succinate dehydrogenase flavoprotein subunit. Robinson KM, et al. J Biol Chem, 1992 May 15. PMID 1577780
  4. SDHA is a tumor suppressor gene causing paraganglioma. Burnichon N, et al. Hum Mol Genet, 2010 Aug 1. PMID 20484225, Free PMC Article
  5. Direct interaction between yeast NADH-ubiquinone oxidoreductase, succinate-ubiquinone oxidoreductase, and ubiquinol-cytochrome c oxidoreductase in the reduction of exogenous quinones. Zhu QS, et al. J Biol Chem, 1988 Jan 5. PMID 2826438

See all (119) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Studies indicate that the flavinylation factor Sdh5 provided insight into the possible mechanism associated with Sdh1 flavinylation.
    Title: Emerging concepts in the flavinylation of succinate dehydrogenase.
  2. The NMR structure of Sdh5 represents the first eukaryotic structure of Pfam family PF03937 and reveals a conserved surface region, which likely represents a putative Sdh1-Sdh5 interaction interface.
    Title: Solution NMR structure of yeast succinate dehydrogenase flavinylation factor Sdh5 reveals a putative Sdh1 binding site.
  3. Sdh5 (originally named EMI5/YOL071W)is required for succinate dehydrogenase(SDH)-dependent respiration and for Sdh1 flavination
    Title: SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.
  4. A decrease in the amount of Sdh1p in the flx1Delta mutant strain has been determined to be due to a post-transcriptional control that involves regulatory sequences located upstream of the SDH1 coding sequence.
    Title: Succinate dehydrogenase flavoprotein subunit expression in Saccharomyces cerevisiae--involvement of the mitochondrial FAD transporter, Flx1p.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables succinate dehydrogenase (FAD) activity IEA
Inferred from Electronic Annotation
more info
  
enables succinate dehydrogenase (quinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate dehydrogenase (quinone) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables succinate dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables succinate dehydrogenase (quinone) activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables succinate dehydrogenase (quinone) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables succinate dehydrogenase (quinone) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to succinate dehydrogenase (quinone) activity RCA
inferred from Reviewed Computational Analysis
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration RCA
inferred from Reviewed Computational Analysis
more info
  
involved_in cellular respiration IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular respiration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in electron transport chain IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial electron transport, succinate to ubiquinone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, succinate to ubiquinone IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tricarboxylic acid cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane RCA
inferred from Reviewed Computational Analysis
more info
  
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex II (succinate dehydrogenase) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex II (succinate dehydrogenase) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex II (succinate dehydrogenase) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of respiratory chain complex II (succinate dehydrogenase) IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
succinate dehydrogenase flavoprotein subunit SDH1
NP_012774.1
  • Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits; mutations in human ortholog SDHA are associated with Leigh syndrome and predisposition to several cancers

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    169207..171129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179714.1 → NP_012774.1  succinate dehydrogenase flavoprotein subunit SDH1

    See identical proteins and their annotated locations for NP_012774.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VX49, Q00711
    UniProtKB/TrEMBL
    A6ZZH4, B3LQV3, C7GSN6, G2WHP1, N1NZP2
    Conserved Domains (1) summary
    cl39091
    Location:46 → 640
    SdhA; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00711.1

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