NNR2 NADHX dehydratase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NNR2
Official Full Name: NADHX dehydratase
Primary source: SGD:S000001634
Locus tag: YKL151C
See related: AllianceGenome:SGD:S000001634; FungiDB:YKL151C; VEuPathDB:YKL151C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ATP-dependent NAD(P)H-hydrate dehydratase activity. Involved in nicotinamide nucleotide metabolic process. Located in cytoplasm. Orthologous to human NAXD (NAD(P)HX dehydratase). [provided by Alliance of Genome Resources, May 2025]
Orthologs: all
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Genomic context

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See NNR2 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (164917..165930, complement)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

at this locus, the intergenic region serves as a focal point of regulatory input, driving antisense expression and mediating the coordinated regulation of YKL151C and GPM1 Together, our findings implicate transcription factors in the joint control of neighboring genes specialized to opposing conditions and the antisense transcripts expressed between them.
Title: The Role of Transcription Factors at Antisense-Expressing Gene Pairs in Yeast.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent NAD(P)H-hydrate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent NAD(P)H-hydrate dehydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP-dependent NAD(P)H-hydrate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables hydro-lyase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in metabolite repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in nicotinamide nucleotide metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nicotinamide nucleotide metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NADHX dehydratase

NP_012771.1

EC 4.2.1.93

Widely-conserved NADHX dehydratase; converts (S)-NADHX to NADH in ATP-dependent manner; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; downstream intergenic region drives antisense expression and mediates coordinated regulation of YKL151C and GPM1 phosphoglycerate mutase; protein abundance increases in response to DNA replication stress; homolog of Carkd in mammals and C-terminus of YjeF in E.coli

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

164917..165930 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179717.1 → NP_012771.1 TPA: NADHX dehydratase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012771.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VX46, P36059, Q6Q5N3

UniProtKB/TrEMBL

A6ZZH1, B3LQV0, C7GSN3, C8ZC24, G2WHN8, N1P149

Conserved Domains (1) summary

TIGR00196
Location:8 → 309

yjeF_cterm; yjeF C-terminal region, hydroxyethylthiazole kinase-related