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CBT1 Cbt1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853673, updated on 23-Apr-2026
Official Symbol
CBT1
Official Full Name
Cbt1p
Primary source
SGD:S000001691
Locus tag
YKL208W
See related
AllianceGenome:SGD:S000001691; FungiDB:YKL208W; VEuPathDB:YKL208W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SOC1
Summary
Involved in cytochrome complex assembly; mRNA processing; and mRNA stabilization. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See CBT1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (47157..47972)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette a-factor transporter STE6 Neighboring gene tRNA-Thr Neighboring gene ER membrane complex subunit EMC3 Neighboring gene Add66p

Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A novel nuclear gene, CBT1, essential for mitochondrial cytochrome b formation: terminal processing of mRNA and intron dependence. Rieger KJ, et al. Curr Genet, 1997 Sep. PMID 9339340
  2. CBT1 interacts genetically with CBP1 and the mitochondrially encoded cytochrome b gene and is required to stabilize the mature cytochrome b mRNA of Saccharomyces cerevisiae. Ellis TP, et al. Genetics, 2005 Nov. PMID 16118200, Free PMC Article
  3. Dbf2 is implicated in a Cbt1-dependent pathway following a shift from glucose to galactose or non-fermentable carbon sources in Saccharomyces cerevisiae. Grandin N, et al. Mol Gen Genet, 1999 Mar. PMID 10102376
  4. Suppressor analysis of mutations in the 5'-untranslated region of COB mRNA identifies components of general pathways for mitochondrial mRNA processing and decay in Saccharomyces cerevisiae. Chen W, et al. Genetics, 1999 Apr. PMID 10101159, Free PMC Article
  5. ATG18 and FAB1 are involved in dehydration stress tolerance in Saccharomyces cerevisiae. López-Martínez G, et al. PLoS One, 2015. PMID 25803831, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Null strains have defects in 5'-end processing of precursor cytochrome b mRNA to the mature form.
    Title: CBT1 interacts genetically with CBP1 and the mitochondrially encoded cytochrome b gene and is required to stabilize the mature cytochrome b mRNA of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cytochrome complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytochrome complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Cbt1p
NP_012714.1
  • Protein involved in 5' RNA end processing; substrates include mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    47157..47972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179773.1 → NP_012714.1  Cbt1p

    See identical proteins and their annotated locations for NP_012714.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWZ5, P36038, Q6Q574
    UniProtKB/TrEMBL
    G2WHI6, N1P0A3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36038.1

Gene LinkOut

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