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JEN1 Jen1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853663, updated on 9-Aug-2022

Summary

Gene symbol
JEN1
Gene description
Jen1p
Primary source
SGD:S000001700
Locus tag
YKL217W
See related
AllianceGenome:SGD:S000001700
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables secondary active monocarboxylate transmembrane transporter activity and selenite:proton symporter activity. Involved in plasma membrane lactate transport; plasma membrane pyruvate transport; and plasma membrane selenite transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See JEN1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (22234..24084)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Cos9p Neighboring gene threo-3-hydroxy-L-aspartate ammonia-lyase SRY1 Neighboring gene dihydroorotate dehydrogenase Neighboring gene 5-oxoprolinase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Process Evidence Code Pubs
involved_in carboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in plasma membrane lactate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in plasma membrane lactate transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in plasma membrane pyruvate transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in plasma membrane selenite transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sialic acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Jen1p
NP_012705.1
  • Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    22234..24084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179782.1NP_012705.1  TPA: Jen1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012705.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWY6, P36035
    UniProtKB/TrEMBL
    A0A8H4C038, N1P0Q3
    Conserved Domains (1) summary
    TIGR00891
    Location:129544
    2A0112; putative sialic acid transporter