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MCH2 Mch2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853659, updated on 23-Apr-2026
Official Symbol
MCH2
Official Full Name
Mch2p
Primary source
SGD:S000001704
Locus tag
YKL221W
See related
AllianceGenome:SGD:S000001704; FungiDB:YKL221W; VEuPathDB:YKL221W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable transmembrane transporter activity. Predicted to act upstream of or within transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cataract 47. Orthologous to several human genes including SLC16A11 (solute carrier family 16 member 11); SLC16A12 (solute carrier family 16 member 12); and SLC16A5 (solute carrier family 16 member 5). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (6107..7528)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene seripauperin PAU16 Neighboring gene uncharacterized protein Neighboring gene ferric/cupric-chelate reductase Neighboring gene Cos9p

Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genome-wide screening of Saccharomyces cerevisiae genes regulated by vanillin. Park EH, et al. J Microbiol Biotechnol, 2015 Jan. PMID 25269814
  2. The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane. Makuc J, et al. Yeast, 2001 Sep 15. PMID 11536335
  3. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Halestrap AP, et al. Biochem J, 1999 Oct 15. PMID 10510291, Free PMC Article
  4. An evolutionarily 'young' lysine residue in histone H3 attenuates transcriptional output in Saccharomyces cerevisiae. Hyland EM, et al. Genes Dev, 2011 Jun 15. PMID 21685365, Free PMC Article
  5. A CRISPR/Cas9-based exploration into the elusive mechanism for lactate export in Saccharomyces cerevisiae. Mans R, et al. FEMS Yeast Res, 2017 Dec 1. PMID 29145596

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
Mch2p
NP_012701.2
  • Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    6107..7528
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179786.2 → NP_012701.2  Mch2p

    See identical proteins and their annotated locations for NP_012701.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWY2, P36032
    UniProtKB/TrEMBL
    B5VLU4, N1P0L6
    Conserved Domains (1) summary
    cd17352
    Location:41 → 428
    MFS_MCT_SLC16; Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36032.2

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