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PRS1 ribose phosphate diphosphokinase subunit PRS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853654, updated on 1-Nov-2019

Summary

Gene symbol
PRS1
Gene description
ribose phosphate diphosphokinase subunit PRS1
Primary source
SGD:S000001664
Locus tag
YKL181W
Gene type
protein coding
RNA name
ribose phosphate diphosphokinase subunit PRS1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PRP1

Genomic context

See PRS1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (107316..108599)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Lot5p Neighboring gene tetrafunctional fatty acid synthase subunit FAS1 Neighboring gene ribosomal 60S subunit protein L17A Neighboring gene Coy1p

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
ribose phosphate diphosphokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribose phosphate diphosphokinase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to ribose phosphate diphosphokinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
5-phosphoribose 1-diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
5-phosphoribose 1-diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
5-phosphoribose 1-diphosphate biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
5-phosphoribose 1-diphosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
fungal-type cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fungal-type cell wall organization IPI
Inferred from Physical Interaction
more info
PubMed 
nucleoside metabolic process IEA
Inferred from Electronic Annotation
more info
 
nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoside monophosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm HDA PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
ribose phosphate diphosphokinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribose phosphate diphosphokinase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribose phosphate diphosphokinase subunit PRS1
NP_012740.1
  • 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; plays a key role in cell wall integrity (CWI) pathway; one of five related enzymes, which are active as heteromultimeric complexes; missense mutations in human homolog PRPS1 are associated with neuropathic Arts syndrome and Charcot-Marie Tooth (CMTX5) disease

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    107316..108599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179747.1NP_012740.1  TPA: ribose phosphate diphosphokinase subunit PRS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012740.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P32895
    Conserved Domains (1) summary
    COG0462
    Location:1422
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
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