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FAS1 tetrafunctional fatty acid synthase subunit FAS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853653, updated on 9-Aug-2022

Summary

Gene symbol
FAS1
Gene description
tetrafunctional fatty acid synthase subunit FAS1
Primary source
SGD:S000001665
Locus tag
YKL182W
See related
AllianceGenome:SGD:S000001665
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity; fatty acid synthase activity; and palmitoyltransferase activity. Contributes to fatty acid synthase activity. Involved in long-chain fatty acid biosynthetic process. Located in cytosol and lipid droplet. Part of fatty acid synthase complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See FAS1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (100671..106826)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Lot5p Neighboring gene ribose phosphate diphosphokinase subunit PRS1 Neighboring gene ribosomal 60S subunit protein L17A

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the FAS1 gene: The FAS1 gene is conserved in S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, and N.crassa.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables S-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables S-malonyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables [acyl-carrier-protein] S-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables [acyl-carrier-protein] S-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables [acyl-carrier-protein] S-acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables [acyl-carrier-protein] S-malonyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables [acyl-carrier-protein] S-malonyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables [acyl-carrier-protein] S-malonyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables acyl-[acyl-carrier-protein] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables enoyl-[acyl-carrier-protein] reductase (NADH) activity IEA
Inferred from Electronic Annotation
more info
 
enables enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables enoyl-[acyl-carrier-protein] reductase activity IEA
Inferred from Electronic Annotation
more info
 
enables fatty acid synthase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to fatty acid synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables fatty-acyl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables myristoyl-[acyl-carrier-protein] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables oleoyl-[acyl-carrier-protein] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables palmitoyl-[acyl-carrier-protein] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables palmitoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in long-chain fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of fatty acid synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of fatty acid synthase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of fatty acid synthase complex IEA
Inferred from Electronic Annotation
more info
 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
tetrafunctional fatty acid synthase subunit FAS1
NP_012739.1
  • Beta subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    100671..106826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179748.1NP_012739.1  TPA: tetrafunctional fatty acid synthase subunit FAS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012739.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P07149, Q05747
    UniProtKB/TrEMBL
    A0A8H4BZA1, N1P0M8
    Conserved Domains (5) summary
    COG0331
    Location:159536
    FabD; Malonyl CoA-acyl carrier protein transacylase [Lipid transport and metabolism]
    COG4981
    Location:5591350
    COG4981; Enoyl reductase domain of yeast-type FAS1 [Lipid transport and metabolism]
    cd03447
    Location:15361660
    FAS_MaoC; the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD).
    pfam00698
    Location:16632037
    Acyl_transf_1; Acyl transferase domain
    pfam17828
    Location:5131
    FAS_N; N-terminal domain in fatty acid synthase subunit beta