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TOR2 phosphatidylinositol kinase-related protein kinase TOR2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853632, updated on 14-Nov-2024

Summary

Official Symbol
TOR2
Official Full Name
phosphatidylinositol kinase-related protein kinase TOR2
Primary source
SGD:S000001686
Locus tag
YKL203C
See related
AllianceGenome:SGD:S000001686; FungiDB:YKL203C; VEuPathDB:YKL203C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DRR2
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including TOR signaling; establishment or maintenance of actin cytoskeleton polarity; and positive regulation of Rho protein signal transduction. Located in fungal-type vacuole membrane and plasma membrane. Part of TORC1 complex and TORC2 complex. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See TOR2 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (55935..63359, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Ran GTPase-binding protein LOS1 Neighboring gene Eap1p Neighboring gene Mnn4p Neighboring gene putative serine/threonine protein kinase PTK1

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol 4-kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to nitrogen starvation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to stress IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment or maintenance of actin cytoskeleton polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of autophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of Rho protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cellular component organization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of macromolecule metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of primary metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of snRNA pseudouridine synthesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosome biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of TOR complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of TORC1 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of TORC2 complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphatidylinositol kinase-related protein kinase TOR2
NP_012719.2
  • PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates plasma membrane (PM) homeostasis and cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; PM retention is dependent on Avo3p; malonyl-CoA is a direct ATP-competitive inhibitor of TORC1; TOR2 has a paralog, TOR1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    55935..63359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179768.1NP_012719.2  TPA: phosphatidylinositol kinase-related protein kinase TOR2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012719.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VX00, P32600
    UniProtKB/TrEMBL
    N1NZF0
    Conserved Domains (2) summary
    COG5032
    Location:2902474
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    sd00044
    Location:599620
    HEAT; HEAT repeat [structural motif]