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HOM6 homoserine dehydrogenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853604, updated on 29-Jun-2024

Summary

Gene symbol
HOM6
Gene description
homoserine dehydrogenase
Primary source
FungiDB:YJR139C
Locus tag
YJR139C
See related
SGD:S000003900; AllianceGenome:SGD:S000003900; VEuPathDB:YJR139C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
THR6
Summary
Enables homoserine dehydrogenase activity. Involved in homoserine biosynthetic process; methionine biosynthetic process; and threonine biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See HOM6 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (689445..690524, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene sulfite reductase (NADPH) subunit beta Neighboring gene GTPase-activating protein IML1 Neighboring gene Hir3p Neighboring gene putative polyadenylation protein

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 
enables homoserine dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables homoserine dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables homoserine dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in aspartate family amino acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in aspartate family amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in homoserine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in homoserine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in methionine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in threonine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in threonine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
homoserine dehydrogenase
NP_012673.3
  • Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase); dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    689445..690524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181797.3NP_012673.3  TPA: homoserine dehydrogenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012673.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWV8, P31116
    UniProtKB/TrEMBL
    A0A6A5PTT7, A6ZQ95, B3LQM1, B5VLS9, C7GM73, C8ZBT8, E9P9D5, G2WHE2, N1P1T8
    Conserved Domains (1) summary
    PRK09436
    Location:2335
    thrA; bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional