IML1 GTPase-activating protein IML1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: IML1
Official Full Name: GTPase-activating protein IML1
Primary source: SGD:S000003899
Locus tag: YJR138W
See related: AllianceGenome:SGD:S000003899; FungiDB:YJR138W; VEuPathDB:YJR138W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SEA1
Summary: Enables GTPase activator activity. Involved in several processes, including cellular response to nitrogen starvation; negative regulation of intracellular signal transduction; and regulation of autophagosome assembly. Acts upstream of or within cellular response to oxidative stress. Located in fungal-type vacuole membrane. Part of GATOR1 complex. Used to study cancer. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy and familial focal epilepsy with variable foci 1. Orthologous to human DEPDC5 (DEP domain containing 5, GATOR1 subcomplex subunit). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTPase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to nitrogen starvation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of TOR signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of small GTPase mediated signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of GATOR1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GATOR1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of Seh1-associated complex	IDA Inferred from Direct Assay more info	PubMed
part_of Seh1-associated complex	IPI Inferred from Physical Interaction more info	PubMed
located_in fungal-type vacuole membrane	HDA more info	PubMed
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	NAS Non-traceable Author Statement more info	PubMed

NP_012672.1

GTPase-activating protein (GAP) subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy, and is a subcomplex of the SEA, a coatomer-related complex that associates with the vacuole; Iml1p functions as a GAP for the Rag family GTPase Gtr1p (EGOC subunit) in SEACIT, resulting in the inhibition of TORC1 signaling in response to amino acid deprivation; role in the oxidative stress response

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