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MNS1 mannosyl-oligosaccharide 1,2-alpha-mannosidase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853595, updated on 2-Oct-2018

Summary

Gene symbol
MNS1
Gene description
mannosyl-oligosaccharide 1,2-alpha-mannosidase
Primary source
SGD:S000003892
Locus tag
YJR131W
Gene type
protein coding
RNA name
mannosyl-oligosaccharide 1,2-alpha-mannosidase
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See MNS1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (667644..669293)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene protein-lysine N-methyltransferase Neighboring gene cystathionine gamma-synthase Neighboring gene Nmd5p Neighboring gene xanthine phosphoribosyltransferase

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the MNS1 gene: The MNS1 gene is conserved in zebrafish, S.cerevisiae, K.lactis, S.pombe, M.oryzae, and N.crassa.

Gene Ontology Provided by GO

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IDA
Inferred from Direct Assay
more info
PubMed 
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
 
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
protein deglycosylation involved in glycoprotein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mannosyl-oligosaccharide 1,2-alpha-mannosidase
NP_012665.3
  • Alpha-1,2-mannosidase; involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    667644..669293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181789.3NP_012665.3  TPA: mannosyl-oligosaccharide 1,2-alpha-mannosidase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012665.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P32906
    Conserved Domains (1) summary
    pfam01532
    Location:45532
    Glyco_hydro_47; Glycosyl hydrolase family 47
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