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IBA57 Iba57p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853586, updated on 11-May-2025
Official Symbol
IBA57
Official Full Name
Iba57p
Primary source
SGD:S000003883
Locus tag
YJR122W
See related
AllianceGenome:SGD:S000003883; FungiDB:YJR122W; VEuPathDB:YJR122W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CAF17
Summary
Predicted to enable transferase activity. Involved in protein maturation. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 74 and multiple mitochondrial dysfunctions syndrome 3. Orthologous to human IBA57 (iron-sulfur cluster assembly factor IBA57). [provided by Alliance of Genome Resources, May 2025]
Orthologs
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See IBA57 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (649776..651269)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Dmo1p Neighboring gene F1F0 ATP synthase subunit beta Neighboring gene ribosomal 40S subunit protein S5 Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Data on the role of iba57p in free Fe(2+) release and O(2)(∙-) generation in Saccharomyces cerevisiae. Gomez-Gallardo M, et al. Data Brief, 2018 Jun. PMID 29900191, Free PMC Article
  2. Iba57p participates in maturation of a [2Fe-2S]-cluster Rieske protein and in formation of supercomplexes III/IV of Saccharomyces cerevisiae electron transport chain. Sánchez LA, et al. Mitochondrion, 2019 Jan. PMID 29343425
  3. Mitochondrial Iba57p is required for Fe/S cluster formation on aconitase and activation of radical SAM enzymes. Gelling C, et al. Mol Cell Biol, 2008 Mar. PMID 18086897, Free PMC Article
  4. Reactive oxygen species production induced by ethanol in Saccharomyces cerevisiae increases because of a dysfunctional mitochondrial iron-sulfur cluster assembly system. Pérez-Gallardo RV, et al. FEMS Yeast Res, 2013 Dec. PMID 24028658
  5. Systematic mutagenesis of the leucine-rich repeat (LRR) domain of CCR4 reveals specific sites for binding to CAF1 and a separate critical role for the LRR in CCR4 deadenylase activity. Clark LB, et al. J Biol Chem, 2004 Apr 2. PMID 14734555

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings suggest that Iba57p participates in maturation of the [2Fe-2S]-cluster into the Rieske protein and that Rieske protein plays important roles in the conformation and functionality of mitochondrial supercomplex III/IV in the electron transport chain.
    Title: Iba57p participates in maturation of a [2Fe-2S]-cluster Rieske protein and in formation of supercomplexes III/IV of Saccharomyces cerevisiae electron transport chain.
  2. Yeast COG0354 represents an ancient, folate-dependent protein family involved in the metabolism of Fe/S cluster containing enzymes
    Title: A role for tetrahydrofolates in the metabolism of iron-sulfur clusters in all domains of life.
  3. Mitochondrial Iba57 is required for Fe/S cluster formation on aconitase and activation of radical SAM enzymes.
    Title: Mitochondrial Iba57p is required for Fe/S cluster formation on aconitase and activation of radical SAM enzymes.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Iba57p
NP_012656.1
  • Protein involved in incorporating iron-sulfur clusters into proteins; mitochondrial matrix protein; involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    649776..651269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181780.1 → NP_012656.1  TPA: Iba57p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012656.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWU1, P47158
    UniProtKB/TrEMBL
    A6ZQ78, B3LQK6, C7GM90, C8ZBS0, G2WHC5, N1P1R9
    Conserved Domains (1) summary
    COG0354
    Location:147 → 492
    YgfZ; Folate-binding Fe-S cluster repair protein YgfZ, possible role in tRNA modification [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47158.1

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