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CPA2 carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2 [ Saccharomyces cerevisiae S288c ]

Gene ID: 853573, updated on 5-Mar-2017
Gene symbol
CPA2
Gene description
carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2
Primary source
SGD:S000003870
Locus tag
YJR109C
Gene type
protein coding
RNA name
carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
See CPA2 in Map Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (629585..632941, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene putative lipase Neighboring gene Abm1p Neighboring gene phosphatidylinositol-3-phosphatase YMR1 Neighboring gene Pxp2p

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NOT aspartate carbamoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
carbamoyl-phosphate synthase (ammonia) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
PubMed 
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
NOT dihydroorotase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
'de novo' pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
arginine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
nitrogen compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
urea cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
carbamoyl-phosphate synthase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Names
carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2
NP_012643.3
  • Large subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    629585..632941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181767.3NP_012643.3  TPA: carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2 [Saccharomyces cerevisiae S288c]

    See identical proteins and their annotated locations for NP_012643.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P03965
    Conserved Domains (5) summary
    cd01423
    Location:9671082
    MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
    TIGR01369
    Location:231084
    CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
    pfam02786
    Location:149351
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    pfam02787
    Location:438567
    CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
    cl17255
    Location:694891
    ATP-grasp_4; ATP-grasp domain
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