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EMC2 Emc2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853550, updated on 6-Jul-2026
Official Symbol
EMC2
Official Full Name
Emc2p
Primary source
SGD:S000003848
Locus tag
YJR088C
See related
AllianceGenome:SGD:S000003848; FungiDB:YJR088C; VEuPathDB:YJR088C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein folding in endoplasmic reticulum. Located in endoplasmic reticulum and nucleus. Part of EMC complex. Orthologous to human EMC2 (ER membrane protein complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See EMC2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (586495..587373, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Tmh11p Neighboring gene Ste18p Neighboring gene survivin Neighboring gene SCF ubiquitin ligase complex subunit GRR1

Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structure of the ER membrane complex, a transmembrane-domain insertase. Bai L, et al. Nature, 2020 Aug. PMID 32494008, Free PMC Article
  2. ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway. Xiao T, et al. Life Sci Alliance, 2021 Mar. PMID 33479049, Free PMC Article
  3. Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex. Richard M, et al. Proc Natl Acad Sci U S A, 2013 Mar 12. PMID 23431131, Free PMC Article
  4. Evidence for interaction between Hsp90 and the ER membrane complex. Kudze T, et al. Cell Stress Chaperones, 2018 Sep. PMID 29808299, Free PMC Article
  5. Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast. Medkour Y, et al. Oncotarget, 2019 Oct 8. PMID 31645900, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to membrane insertase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to membrane insertase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in phospholipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding in endoplasmic reticulum HGI PubMed 
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tail-anchored membrane protein insertion into ER membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in EMC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of EMC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of EMC complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum membrane EXP
Inferred from Experiment
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
Preferred Names
Emc2p
NP_012621.1
  • Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    586495..587373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181745.1 → NP_012621.1  Emc2p

    See identical proteins and their annotated locations for NP_012621.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWQ6, P47133, Q66R61
    UniProtKB/TrEMBL
    B3LQH2
    Conserved Domains (1) summary
    sd00006
    Location:163 → 191
    TPR; TPR repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47133.1

Gene LinkOut

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