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TOR1 phosphatidylinositol kinase-related protein kinase TOR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853529, updated on 4-Aug-2019

Summary

Gene symbol
TOR1
Gene description
phosphatidylinositol kinase-related protein kinase TOR1
Primary source
SGD:S000003827
Locus tag
YJR066W
Gene type
protein coding
RNA name
phosphatidylinositol kinase-related protein kinase TOR1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DRR1

Genomic context

See TOR1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (559416..566828)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene chaperonin-containing T-complex subunit CCT5 Neighboring gene actin-related protein 3 Neighboring gene Yae1p Neighboring gene replication factor C subunit 2

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • 3-phosphoinositide biosynthesis, organism-specific biosystem (from BIOCYC)
    3-phosphoinositide biosynthesis, organism-specific biosystem
    3-phosphoinositide biosynthesis
  • Autophagy - other, organism-specific biosystem (from KEGG)
    Autophagy - other, organism-specific biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
  • Autophagy - other, conserved biosystem (from KEGG)
    Autophagy - other, conserved biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
  • Autophagy - yeast, organism-specific biosystem (from KEGG)
    Autophagy - yeast, organism-specific biosystemAutophagy is a non-selective and bulk intracellular degradation system of eukaryotic cells and is highly conserved from yeast to human. In this process, the double-membrane vesicle, known as autophag...
  • Autophagy - yeast, conserved biosystem (from KEGG)
    Autophagy - yeast, conserved biosystemAutophagy is a non-selective and bulk intracellular degradation system of eukaryotic cells and is highly conserved from yeast to human. In this process, the double-membrane vesicle, known as autophag...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Longevity regulating pathway - multiple species, organism-specific biosystem (from KEGG)
    Longevity regulating pathway - multiple species, organism-specific biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
  • Longevity regulating pathway - multiple species, conserved biosystem (from KEGG)
    Longevity regulating pathway - multiple species, conserved biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
  • Mitophagy - yeast, organism-specific biosystem (from KEGG)
    Mitophagy - yeast, organism-specific biosystemMitophagy, which refers to the selective elimination of impaired or excessive mitochondria, is considered to be the main mechanism for mitochondria quality and quantity control. In yeast, oxidative s...
  • Mitophagy - yeast, conserved biosystem (from KEGG)
    Mitophagy - yeast, conserved biosystemMitophagy, which refers to the selective elimination of impaired or excessive mitochondria, is considered to be the main mechanism for mitochondria quality and quantity control. In yeast, oxidative s...
  • Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystem (from REACTOME)
    Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Nonsense-Mediated Decay (NMD), organism-specific biosystem (from REACTOME)
    Nonsense-Mediated Decay (NMD), organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • phosphatidylinositol phosphate biosynthesis, organism-specific biosystem (from BIOCYC)
    phosphatidylinositol phosphate biosynthesis, organism-specific biosystemThe phosphorylated products of phosphatidylinositol (PtdIns, PI), collectively referred to as phosphoinositides or phosphatidylinositol phosphates (PtdInsPs, PIPs), are membrane-bound lipids that fun...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
TOR signaling IC
Inferred by Curator
more info
PubMed 
TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to heat IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
chronological cell aging IGI
Inferred from Genetic Interaction
more info
PubMed 
fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondria-nucleus signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of autophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein kinase activity by regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleolar large rRNA transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of snRNA pseudouridine synthesis IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosome biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
TORC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
TORC1 complex IPI
Inferred from Physical Interaction
more info
PubMed 
TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
fungal-type vacuole membrane HDA PubMed 
fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
vacuolar membrane IEA
Inferred from Electronic Annotation
more info
 
vacuole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphatidylinositol kinase-related protein kinase TOR1
NP_012600.1
  • PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    559416..566828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181724.1NP_012600.1  TPA: phosphatidylinositol kinase-related protein kinase TOR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012600.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35169
    Conserved Domains (7) summary
    COG5032
    Location:2792470
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05169
    Location:20902366
    PIKKc_TOR; Catalytic domain of Target of Rapamycin
    pfam02260
    Location:24392470
    FATC; FATC domain
    pfam08771
    Location:19522049
    Rapamycin_bind; Rapamycin binding domain
    pfam11865
    Location:827986
    DUF3385; Domain of unknown function (DUF3385)
    pfam13513
    Location:771820
    HEAT_EZ; HEAT-like repeat
    sd00044
    Location:588620
    HEAT; HEAT repeat [structural motif]
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