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MNN14 Mnn14p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853524, updated on 5-Jul-2025
Official Symbol
MNN14
Official Full Name
Mnn14p
Primary source
SGD:S000003822
Locus tag
YJR061W
See related
AllianceGenome:SGD:S000003822; FungiDB:YJR061W; VEuPathDB:YJR061W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in N-glycan processing. Predicted to be located in Golgi membrane. Human ortholog(s) of this gene implicated in dilated cardiomyopathy (multiple) and muscular dystrophy (multiple). Orthologous to human FKTN (fukutin). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (550511..553318)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene protein kinase PTK2 Neighboring gene Cbf1p Neighboring gene amidase Neighboring gene DNA-directed RNA polymerase I core subunit RPA12

Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Abolishment of N-glycan mannosylphosphorylation in glyco-engineered Saccharomyces cerevisiae by double disruption of MNN4 and MNN14 genes. Kim YH, et al. Appl Microbiol Biotechnol, 2017 Apr. PMID 28101612
  2. The transcription factor Rim101p governs ion tolerance and cell differentiation by direct repression of the regulatory genes NRG1 and SMP1 in Saccharomyces cerevisiae. Lamb TM, et al. Mol Cell Biol, 2003 Jan. PMID 12509465, Free PMC Article
  3. Screening for new yeast mutants affected in mannosylphosphorylation of cell wall mannoproteins. Conde R, et al. Yeast, 2003 Oct 30. PMID 14587103
  4. Identification of novel Saccharomyces cerevisiae proteins with nuclear export activity: cell cycle-regulated transcription factor ace2p shows cell cycle-independent nucleocytoplasmic shuttling. Jensen TH, et al. Mol Cell Biol, 2000 Nov. PMID 11027275, Free PMC Article
  5. Identification and characterization of Prp45p and Prp46p, essential pre-mRNA splicing factors. Albers M, et al. RNA, 2003 Jan. PMID 12554883, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in glycoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Mnn14p
NP_012595.1
  • Protein required for N-glycan mannosylphosphorylation; non-essential gene; transcription repressed by Rm101p; MNN14 has a paralog, MNN4, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    550511..553318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181719.1 → NP_012595.1  TPA: Mnn14p

    See identical proteins and their annotated locations for NP_012595.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWN2, P40355
    UniProtKB/TrEMBL
    C8ZBK9, N1P041
    Conserved Domains (1) summary
    pfam04991
    Location:470 → 720
    LicD; LicD family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40355.2

Gene LinkOut

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