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CBF1 Cbf1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853523, updated on 5-Sep-2021

Summary

Gene symbol
CBF1
Gene description
Cbf1p
Primary source
SGD:S000003821
Locus tag
YJR060W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CEP1; CPF1
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Genomic context

See CBF1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (548759..549814)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Aps2p Neighboring gene protein kinase PTK2 Neighboring gene Mnn14p Neighboring gene amidase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Component Evidence Code Pubs
part_of Cbf1-Met4-Met28 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in kinetochore IPI
Inferred from Physical Interaction
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Cbf1p
NP_012594.1
  • Basic helix-loop-helix (bHLH) protein; forms homodimer to bind E-box consensus sequence CACGTG present at MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins, required for chromosome segregation; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    548759..549814
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181718.1NP_012594.1  TPA: Cbf1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012594.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P17106
    Conserved Domains (1) summary
    cd00083
    Location:220272
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
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