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CYC1 cytochrome c isoform 1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853507, updated on 17-May-2024

Summary

Gene symbol
CYC1
Gene description
cytochrome c isoform 1
Primary source
FungiDB:YJR048W
Locus tag
YJR048W
See related
SGD:S000003809; AllianceGenome:SGD:S000003809
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cardiolipin binding activity and electron transfer activity. Involved in mitochondrial electron transport, cytochrome c to oxygen and mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrial intermembrane space. Used to study hyperglycemia and thrombocytopenia. Human ortholog(s) of this gene implicated in cholangiocarcinoma; lung non-small cell carcinoma; pancreatic cancer; and thrombocytopenia. Orthologous to human CYCS (cytochrome c, somatic). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (526335..526664)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene translation elongation factor eIF-5A Neighboring gene NADH/NAD(+) kinase Neighboring gene Isy1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cardiolipin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables electron transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome c isoform 1
NP_012582.1
  • Cytochrome c, isoform 1; also known as iso-1-cytochrome c; electron carrier of mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication; human homolog CYC1 can complement yeast null mutant; mutations in human CYC1 cause insulin-responsive hyperglycemia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    526335..526664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181706.1NP_012582.1  TPA: cytochrome c isoform 1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012582.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWL9, P00044
    UniProtKB/TrEMBL
    A0A6A5PXE3, A6ZQ07, B3LQD7, C7GVF8, C8ZBJ8, G2WH53, N1P029
    Conserved Domains (1) summary
    COG3474
    Location:1109
    Cyc7; Cytochrome c2 [Energy production and conversion]