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MET3 sulfate adenylyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853466, updated on 18-Sep-2024

Summary

Official Symbol
MET3
Official Full Name
sulfate adenylyltransferase
Primary source
SGD:S000003771
Locus tag
YJR010W
See related
AllianceGenome:SGD:S000003771; FungiDB:YJR010W; VEuPathDB:YJR010W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables sulfate adenylyltransferase (ATP) activity. Involved in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) and sulfur amino acid metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Pakistani type. Orthologous to human PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) and PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See MET3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (456239..457774)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Mho1p Neighboring gene glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2 Neighboring gene signal peptidase complex subunit SPC1 Neighboring gene Cal4p

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables sulfate adenylyltransferase (ATP) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sulfate adenylyltransferase (ATP) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sulfate adenylyltransferase (ATP) activity IEA
Inferred from Electronic Annotation
more info
 
enables sulfate adenylyltransferase (ATP) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
sulfate adenylyltransferase
NP_012543.3
  • ATP sulfurylase; catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    456239..457774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181668.3NP_012543.3  TPA: sulfate adenylyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012543.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWI5, P08536, Q66R66
    UniProtKB/TrEMBL
    A6ZPX7, B3LQA9, C7GWK0, D3UF76, N1P8M1
    Conserved Domains (1) summary
    TIGR00339
    Location:4386
    sopT; ATP sulphurylase