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POL31 DNA-directed DNA polymerase delta subunit POL31 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853462, updated on 14-Nov-2024

Summary

Official Symbol
POL31
Official Full Name
DNA-directed DNA polymerase delta subunit POL31
Primary source
SGD:S000003766
Locus tag
YJR006W
See related
AllianceGenome:SGD:S000003766; FungiDB:YJR006W; VEuPathDB:YJR006W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HUS2; HYS2; SDP5
Summary
Enables DNA-directed DNA polymerase activity. Involved in DNA replication, removal of RNA primer and RNA-templated DNA biosynthetic process. Located in cytosol and nucleus. Part of zeta DNA polymerase complex. Used to study cancer. Orthologous to human POLD2 (DNA polymerase delta 2, accessory subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See POL31 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (449202..450665)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Apl1p Neighboring gene Lso1p Neighboring gene translation initiation factor eIF2 subunit alpha Neighboring gene Mho1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-directed DNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA-directed DNA polymerase activity TAS
Traceable Author Statement
more info
PubMed 
contributes_to single-stranded DNA 3'-5' DNA exonuclease activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of delta DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of delta DNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
part_of delta DNA polymerase complex TAS
Traceable Author Statement
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of zeta DNA polymerase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA-directed DNA polymerase delta subunit POL31
NP_012539.1
  • Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair; forms a complex with Rev3p, Rev7p and Pol32p; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    449202..450665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181663.1NP_012539.1  TPA: DNA-directed DNA polymerase delta subunit POL31 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012539.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWI1, P46957
    UniProtKB/TrEMBL
    D3UF73, N1P1G3
    Conserved Domains (1) summary
    COG1311
    Location:5487
    HYS2; Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B [Replication, recombination and repair]