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COX16 Cox16p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853454, updated on 15-Mar-2026
Official Symbol
COX16
Official Full Name
Cox16p
Primary source
SGD:S000003540
Locus tag
YJL003W
See related
AllianceGenome:SGD:S000003540; FungiDB:YJL003W; VEuPathDB:YJL003W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 22. Orthologous to human COX16 (cytochrome c oxidase assembly factor COX16). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See COX16 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (432644..433000)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene adenylate cyclase Neighboring gene Sys1p Neighboring gene dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1 Neighboring gene proteasome core particle subunit beta 1

Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. COX16 encodes a novel protein required for the assembly of cytochrome oxidase in Saccharomyces cerevisiae. Carlson CG, et al. J Biol Chem, 2003 Feb 7. PMID 12446688
  2. COX16 is required for assembly of cytochrome c oxidase in human cells and is involved in copper delivery to COX2. Cerqua C, et al. Biochim Biophys Acta Bioenerg, 2018 Apr. PMID 29355485
  3. Cox16 protein is physically associated with Cox1p assembly intermediates and with cytochrome oxidase. Su CH, et al. J Biol Chem, 2017 Sep 29. PMID 28821616, Free PMC Article
  4. Sensitivity to Sn2+ of the yeast Saccharomyces cerevisiae depends on general energy metabolism, metal transport, anti-oxidative defences, and DNA repair. Viau C, et al. Biometals, 2006 Dec. PMID 16691319
  5. Phenomic and transcriptomic analyses reveal that autophagy plays a major role in desiccation tolerance in Saccharomyces cerevisiae. Ratnakumar S, et al. Mol Biosyst, 2011 Jan. PMID 20963216

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex IV assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex IV assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
Preferred Names
Cox16p
NP_012531.1
  • Mitochondrial inner membrane protein; required for assembly of cytochrome c oxidase

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    432644..433000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181437.1 → NP_012531.1  Cox16p

    See identical proteins and their annotated locations for NP_012531.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWH2, P47081
    UniProtKB/TrEMBL
    A6ZPW4, B3LQ96, C7GUU2, D3UF66, G2WH07, N1P1F4
    Conserved Domains (1) summary
    pfam14138
    Location:35 → 111
    COX16; Cytochrome c oxidase assembly protein COX16
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47081.1

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