BBC1 Bbc1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: BBC1
Official Full Name: Bbc1p
Primary source: SGD:S000003557
Locus tag: YJL020C
See related: AllianceGenome:SGD:S000003557; FungiDB:YJL020C; VEuPathDB:YJL020C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MTI1; YJL021C
Summary: Enables myosin I tail binding activity. Involved in actin cytoskeleton organization and negative regulation of Arp2/3 complex-mediated actin nucleation. Is active in actin cortical patch. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Mtl1 is characterized for as a cell-wall sensor of oxidative stress.
Title: Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables myosin I binding	IPI Inferred from Physical Interaction more info	PubMed
enables myosin I tail binding	IDA Inferred from Direct Assay more info	PubMed
enables myosin I tail binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cortical patch	IDA Inferred from Direct Assay more info	PubMed
located_in actin cortical patch	IDA Inferred from Direct Assay more info	PubMed
located_in actin cortical patch	IEA Inferred from Electronic Annotation more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info

NP_012514.2

Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches

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The following sections contain reference sequences that belong to a specific genome build. Explain