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BBC1 Bbc1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853433, updated on 4-Jun-2023

Summary

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Gene symbol
BBC1
Gene description
Bbc1p
Primary source
SGD:S000003557
Locus tag
YJL020C
See related
AllianceGenome:SGD:S000003557
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MTI1; YJL021C
Summary
Predicted to enable actin filament binding activity and phosphatidylinositol binding activity. Involved in actin cytoskeleton organization and negative regulation of Arp2/3 complex-mediated actin nucleation. Located in actin cortical patch. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BBC1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (398937..402410, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene Pet130p Neighboring gene Mps3p Neighboring gene Tph3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Actin-generated force applied during endocytosis measured by Sla2-based FRET tension sensors. Abella M, et al. Dev Cell, 2021 Sep 13. PMID 34473942
  2. Type-I myosins promote actin polymerization to drive membrane bending in endocytosis. Manenschijn HE, et al. Elife, 2019 Aug 6. PMID 31385806, Free PMC Article
  3. Novel function of a dynein light chain in actin assembly during clathrin-mediated endocytosis. Farrell KB, et al. J Cell Biol, 2017 Aug 7. PMID 28706108, Free PMC Article
  4. Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress. Vilella F, et al. J Biol Chem, 2005 Mar 11. PMID 15637049
  5. Negative regulation of yeast WASp by two SH3 domain-containing proteins. Rodal AA, et al. Curr Biol, 2003 Jun 17. PMID 12814545

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mtl1 is characterized for as a cell-wall sensor of oxidative stress.
    Title: Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables myosin I tail binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables myosin I tail binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin cortical patch IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
Bbc1p
NP_012514.2
  • Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    398937..402410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181454.1 → NP_012514.2  TPA: Bbc1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012514.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P47068, Q8X1F4
    UniProtKB/TrEMBL
    A0A8H4BYR9, N1P0Y5
    Conserved Domains (2) summary
    cd11887
    Location:7 → 66
    SH3_Bbc1; Src Homology 3 domain of Bbc1 and similar domains
    TIGR03835
    Location:38 → 386
    termin_org_DnaJ; terminal organelle assembly protein TopJ
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47068.2

Gene LinkOut

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