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APS3 Aps3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853429, updated on 10-Mar-2023

Summary

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Gene symbol
APS3
Gene description
Aps3p
Primary source
SGD:S000003561
Locus tag
YJL024C
See related
AllianceGenome:SGD:S000003561
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YKS7
Summary
Involved in Golgi to vacuole transport and protein targeting to vacuole. Part of AP-3 adaptor complex. Orthologous to human AP3S1 (adaptor related protein complex 3 subunit sigma 1) and AP3S2 (adaptor related protein complex 3 subunit sigma 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See APS3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
2
Sequence:
Chromosome: X; NC_001142.9 (395931..396592, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene ribonucleotide-diphosphate reductase subunit RNR2 Neighboring gene Rrn7p Neighboring gene tRNA-Gly Neighboring gene Pet130p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A dileucine-like sorting signal directs transport into an AP-3-dependent, clathrin-independent pathway to the yeast vacuole. Vowels JJ, et al. EMBO J, 1998 May 1. PMID 9564031, Free PMC Article
  2. A genome-wide copper-sensitized screen identifies novel regulators of mitochondrial cytochrome c oxidase activity. Garza NM, et al. J Biol Chem, 2021 Jan-Jun. PMID 33662401, Free PMC Article
  3. The yeast adaptor protein complex, AP-3, is essential for the efficient delivery of alkaline phosphatase by the alternate pathway to the vacuole. Stepp JD, et al. J Cell Biol, 1997 Dec 29. PMID 9412470, Free PMC Article
  4. The AP-3 adaptor complex mediates sorting of yeast and mammalian PQ-loop-family basic amino acid transporters to the vacuolar/lysosomal membrane. Llinares E, et al. Sci Rep, 2015 Nov 18. PMID 26577948, Free PMC Article
  5. The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cowles CR, et al. Cell, 1997 Oct 3. PMID 9335339

See all (45) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Homologs of the APS3 gene: The APS3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, and N.crassa.
  • Orthologs

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Golgi to vacuole transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-3 adaptor complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Aps3p
NP_012510.3
  • Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    395931..396592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181458.3 → NP_012510.3  TPA: Aps3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012510.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWF8, P47064
    UniProtKB/TrEMBL
    A0A0L8VNQ4, A0A6C1DUI4, A6ZPV0, B3LQ85, C8ZBD5, G2WGZ2, N1P1E1
    Conserved Domains (1) summary
    COG5030
    Location:1 → 172
    APS2; Clathrin adaptor complex, small subunit [Intracellular trafficking and secretion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47064.1

Gene LinkOut

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